Contraception
Volume 53, Issue 1 , Pages 37-40, January 1996

Androgen levels in women using a single implant of nomegestrol acetate

  • Ione Barbosa

      Affiliations

    • Corresponding Author InformationName and address for correspondence: Dr. Ione C. Barbosa, Maternidade Climerio de Oliveira, Rua do Limoeiro, No. 1, Salvador, 40.055-150, Bahia, Brazil. Tel: (071) 243-0003, Fax: (071) 243-9153
    • Maternidade Climerio de Oliveira, Federal University of Bahia, Rua do Limoeiro, No. 1, 40.055-150 Salvador, Bahia, Brazil
    • ,
  • Elsimar Coutinho

      Affiliations

    • Maternidade Climerio de Oliveira, Federal University of Bahia, Rua do Limoeiro, No. 1, 40.055-150 Salvador, Bahia, Brazil
    • ,
  • Celia Athayde

      Affiliations

    • Maternidade Climerio de Oliveira, Federal University of Bahia, Rua do Limoeiro, No. 1, 40.055-150 Salvador, Bahia, Brazil
    • ,
  • O.A. Ladipo

      Affiliations

    • Maternidade Climerio de Oliveira, Federal University of Bahia, Rua do Limoeiro, No. 1, 40.055-150 Salvador, Bahia, Brazil
    • ,
  • Sven-Eric Olsson

      Affiliations

    • Department of Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    • ,
  • Ulf Ulmsten

      Affiliations

    • Department of Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden

Received 24 July 1995; received in revised form 2 October 1995; accepted 6 October 1995.

Abstract 

This study was undertaken to evaluate the effects of a single implant containing nomegestrol acetate (Uniplant) on plasma levels of sex hormone-binding globulin (SHBG), testosterone, free testosterone, androstenedione and on blood pressure, body weight and the development of acne vulgaris. Plasma levels of sex hormone-binding globulin, testosterone, free testosterone and androstenedione were measured. Blood pressure and body weight were determined. The development of acne vulgaris was evaluated. Total testosterone and androstenedione decreased significantly during two years of Uniplant use but all levels were within the normal range. There were no significant differences in sex hormone-binding globulin and free testosterone during 24 months of Uniplant use. All changes observed in this study were within the normal range. SHBG was not affected by Uniplant use. No significant increase in androgen levels and in the development of acne vulgaris was observed in these women using nomegestrol acetate implant during two years. Based on these results, it is possible to conclude that Uniplant had no androgenic effect in women during this study.

Keywords:  Uniplant, SHBG, testosterone, free testosterone, androstenedione

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PII: 0010-7824(95)00256-1

Contraception
Volume 53, Issue 1 , Pages 37-40, January 1996

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