Contraception
Volume 71, Issue 3 , Pages 183-187, March 2005

Comparison of the metabolic effects of oral contraceptive and nonhormonal contraceptive use in women over 40 years old

  • Sawittri Suwikrom

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathumthani, 12121, Thailand
    • Corresponding Author InformationCorresponding author. 33/209 Soi Chokchai 4 Ladpraw Road, Ladpraw, Bangkok, 10230 Thailand. Tel.: +66 1 933 8455; fax: +66 2 514 0435.
    • ,
  • Unnop Jaisamrarn

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand

Received 17 March 2004; received in revised form 23 September 2004; accepted 4 October 2004.

Abstract 

The aim of this study was to compare metabolic changes during use of low-dose combined oral contraceptives (COCs) and those of nonhormonal contraceptives in perimenopausal women. Thirty-nine healthy women over 40 years old who attended the Family Planning Clinic of the King Chulalongkorn Memorial Hospital, Bangkok, Thailand, were recruited, 20 in the COC group received COC preparations containing 30 μg of ethinyl estradiol and 150 μg of levonorgestrel and 19 in the nonhormonal group were intrauterine device users. Blood samples were taken upon admission and 6 months later.

Minor biochemical changes associated with low-dose COC use included an increase in glucose tolerance, triglycerides, serum albumin, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels but a decrease in fasting plasma glucose, total cholesterol, high-density lipoprotein cholesterol, total bilirubin and alkaline phosphatase levels. There was no clinical significance for the metabolic changes. Low-dose COCs can be a satisfactory contraceptive choice for healthy perimenopausal women.

Keywords: Oral contraceptive, Perimenopausal women, Metabolic change

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PII: S0010-7824(04)00271-9

doi:10.1016/j.contraception.2004.10.002

Contraception
Volume 71, Issue 3 , Pages 183-187, March 2005

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