Effect of contraceptive pill on the selenium and zinc status of healthy subjects☆
Received 13 April 2008; received in revised form 5 November 2008; accepted 22 January 2009. published online 06 April 2009.
Abstract
Background
The study was conducted to ascertain the influence of oral contraceptive pill (OCP) uptake on serum zinc and selenium in contraceptive pill users.
Study Design
The concentration of zinc and selenium was determined by atomic absorption spectrophotometer in 50 healthy women with normal menstrual cycles as a control group and 50 women taking low-dose OCP.
Results
The control reference values were 81.61±9.44 and 70.35±25.57 mcg/dL, which were obtained for zinc and selenium, respectively. Use of OCP resulted in a significant decrease in serum zinc levels (p≤.009, t=−3.666) and alteration of selenium levels but not significantly (p=.08, t=0.935). The duration of use beyond 3 months had no effect on the magnitude of the decrease in serum zinc levels.
Conclusions
These findings may be important because selenium is currently believed to offer protective benefits against carcinogenesis. It has been thought that the decrease in serum zinc could be reflected in a reduction of tissue zinc status due to changes in zinc absorption, excretion or tissue turnover. If these changes occur, the dietary zinc requirement would be greater in women using OCP.
Iran University of Medical Sciences, P.O. Box 1449614525, Tehran, Iran
Corresponding author. Biochemistry Department of Medicine Faculty, Iran University of Medical Sciences, P.O. Box 1449614525, Tehran, Iran. Tel.: +98 21 88058742x3116; fax: +98 21 88058742x3116.
☆ This study was supported in part by a grant from the Medical Sciences of Iran University.
ABSTRACT