Two-year clinical efficacy trial with dose variations of a vas deferens injectable contraceptive for the male

Guha, Sujoy K; Singh, Gulshanjit; Srivastava, Anil; Das, H.C; Bhardwaj, J.C; Mathur, Vineet; Koul, Veena; Malhotra, R.L; Das, S.K

« PreviousContraception
Volume 58, Issue 3 , Pages 165-174, September 1998

Two-year clinical efficacy trial with dose variations of a vas deferens injectable contraceptive for the male

Sujoy K Guha
- Centre for Biomedical Engineering, Indian Institute of Technology; All-India Institute of Medical Sciences, New Delhi, India
- Name and address for correspondence: Dr. Sujoy K. Guha, 9 West Avenue, Indian Institute of Technology, New Delhi—110 016, India; Fax: +91-11-686-2037
Gulshanjit Singh
- Department of Surgery, Deen Dayal Upadhyay Hospital, New Delhi, India
Anil Srivastava
- Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, India
H.C Das
- Male Family Planning Unit, L.N.J.P. Hospital, New Delhi, India
J.C Bhardwaj
- Centre for Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, India
Vineet Mathur
- Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, India
Veena Koul
- Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, India
R.L Malhotra
- Male Family Planning Unit, Safdarjung Hospital, New Delhi, India
S.K Das
- Department of Obstetrics and Gynaecology, Safdarjung Hospital, New Delhi, India

Received 3 April 1998; received in revised form 11 August 1998; accepted 11 August 1998.

Abstract

Contraceptive action of a single intra–vas deferens injection of a specific preparation of styrene maleic anhydride (SMA) dissolved in dimethyl sulphoxide, forming a drug given the name Risug®, has been demonstrated earlier. Now fertility control over a 2-year period with doses having the SMA component ranging from 40 to 70 mg is reported here. The results suggest that pregnancy protection is obtained both in the azoospermic and non-azoospermic states. Side effects are minimal and transient in nature. Libido remains unaltered.

Keywords: single injection, vas deferens, male, pregnancy protection, libido maintenance