Contraception
Volume 63, Issue 6 , Pages 329-333 , June 2001

Meloxicam inhibits rabbit ovulation☆

  • A.S Salhab

      Affiliations

    • Department of Pharmacology, University of Jordan, Amman, Jordan
    • Corresponding Author InformationCorresponding author. Tel.: +9626-5355000 (Ext. 2465/2464); fax: +9626-5355500
    • ,
  • M.N Gharaibeh

      Affiliations

    • Department of Pharmacology, University of Jordan, Amman, Jordan
    • ,
  • M.S Shomaf

      Affiliations

    • Department of Pathology, Faculty of Medicine, University of Jordan, Amman, Jordan
    • ,
  • B.I Amro

      Affiliations

    • Faculty of Pharmacy, University of Jordan, Amman, Jordan

References 

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  3. Kujubu DS, Fletcher BS, Varnum BS, Lim RW, Herschman HRJ. T1 S1O, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem. 1991;266:12866–12872
  4. Xie WL, Chipman JG, Robertson DL, Erickson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA. 1991;88:2692–2696
  5. Mitchell JA, Akarasereenot P, Thiemermann C, Flower R, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA. 1993;90:11693–11697
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  8. Richards J. Hormonal control of gene expression in the ovary. Endocr Rev. 1994;15:725–751
  9. Tsafriri A. Ovulation as a tissue remodelling process. Proteolysis and cumulus expansion. Adv Exp Med Biol. 1995;377:121–140
  10. Espey LL, Stein VI, Dumitrescu J. Survey of antiinflammatory agents and related drugs as inhibitors of ovulation in the rabbit. Fertil Steril. 1982;38:238–247
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  13. Lim H, Paria BC, Das Sk, et al.  Multiple female reproductive failures in cyclooxygenase-2 deficient mice. Cell. 1997;91:197–208
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  15. Orczyk GP, Behrman HR. Ovulation blockade by aspirin or indomethacin. In vivo evidence for role of prostaglandin in gonadotrophin secretion. Prostaglandins. 1972;1:3–20
  16. Armstrong DT, Grinwich DL. Blockade of spontaneous and LH-induced ovulation in rats by indomethacin, an inhibitor of prostaglandin biosynthesis. Prostaglandins. 1972;1:21–36
  17. Lau 1F, Saksena SK, Chang MC. Pregnancy blockade by indomethacin, an inhibitor of prostaglandin synthesis (its reversal by prostaglandins and progesterone in mice). Prostaglandins. 1972;4:794–803
  18. Akinlosotu BA, Verna OP. Detection of ovulation in goats by blood prostaglandins concentration. Am J Vet Res. 1983;44:1339–1343
  19. Jaszczak SE. Anovulatory luteal phase in primates. Contraception. 1983;27:505–514
  20. Vane JR, Botting RM. New insight into the mode of action of antiinflammatory drugs. Inflamm Res. 1995;44:1–10
  21. Emery P. Clinical aspects of COX-2 inhibitors. Drugs Today. 1999;35:267–274
  22. Kaufman RA, Savoy , Moore RT, Subramanian MG, Moghissi KS. Cocaine inhibits mating-induced, but not human chorionic gonadotropin-stimulated ovulation in the rabbit. Biol Reprod. 1992;46:641–647
  23. Lehmann NA, Baumeister M, Lutzen L, Wiegleb J. Meloxicam (a toxicological overview). Inflammopharmacology. 1996;4:105–123
  24. Smith G, Roberts R, Hall C, Nuki G. Reversible ovulatory failure associated with the development of luteinized unruptured follicles in women with inflammatory arthritis taking non-steroidal anti-inflammatory drugs. Br J Rheumatol. 1996;35:458–462
  25. Akil M, Amos RS, Stewart P. Infertility may sometimes be associated with NSAID consumption. Br J Rheumatol. 1996;35:76–78
  26. Athanasiou S, Bourne TH, Khalid A, et al.  Effects of indomethacin on follicular structure, vascularity, and function over the periovulatory period in women. Fert Steril. 1996;65:556–560
  27. Manuel D. Meloxicam clinical data on a preferential cyclooxygenase-2 inhibitor. J Clin Rheumatol. 1998;4:S32–S39

PII: S0010-7824(01)00207-4

Contraception
Volume 63, Issue 6 , Pages 329-333 , June 2001

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