Contraception
Volume 67, Issue 1 , Pages 57-64 , January 2003

Effect of temperature and pH on contraceptive gel viscosity

  • Derek H Owen

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-919-660-5182; fax: +1-919-684-4488.
  • ,
  • Jennifer J Peters

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
  • ,
  • Michael L Lavine

      Affiliations

    • Institute of Statistics and Decision Science, Duke University, Durham, NC 27708, USA
  • ,
  • David F Katz

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    • Department of Obstetrics and Gynecology, Duke University, Durham, NC 27708, USA

Received 19 December 2001 ,Revised 6 August 2002 ,Accepted 9 September 2002.

References 

  1. International Working Group on Vaginal Microbicides . Recommendations for the development of vaginal microbicides. AIDS. 1996;10:1–6
  2. Katz DF, Henderson MH, Owen DH, Plenys AM, Walmer DK. What is needed to advance vaginal formulation technology?. In:  Rencher WF editors. Vaginal microbicide formulations workshop. Philadelphia: Lippincott-Raven Publishers; 1998;p. 90–99
  3. Owen DH, Peters JJ, Katz DF. Rheological properties of contraceptive gels. Contraception. 2000;62:321–326
  4. Owen DH, Katz DF. A vaginal fluid simulant. Contraception. 1999;59:91–95
  5. Hirsch IH, Jeyendran RS, Sedor J, Rosecrans RR, Staas WE. Biochemical analysis of electroejaculates in spinal cord injured men (comparison to normal ejaculates). J Urol. 1991;145:73–76
  6. Homonnai ZT, Paz G, Weiss JN, David MP. Quality of semen obtained from 627 fertile men. Int J Androl. 1980;3:217–228
  7. Nagy F, Pendergrass PB, Bowen DC, Yeager JC. A comparative study of cytological and physiological parameters of semen obtained from alcoholics and non-alcoholics. Alcohol Alcohol. 1986;21:17–23
  8. Mandal A, Bhattacharyya AK. Differences in osmolality, pH, buffering capacity, superoxide dismutase and maintenance of sperm motility in human ejaculates according to the degree of coagulation. Int J Androl. 1987;11:45–51
  9. Shedovsky L, Belcher D, Levenstein I. Titrations of human seminal fluid with acids and alkalis and their effects on the survival of sperm motility. Am J Physiol. 1942;136:535–541
  10. Wolters-Everhardt E, Dony JMJ, Lemmens WAJG, Doesbury WH, De Pont JJHHM. Buffering capacity of human semen. Fertil Steril. 1986;46:114–119
  11. Gopalkrishman K, Hinduja IN, Kumar TC. Determining the osmolality of seminal fluid aids in the rapid diagnosis of the fertilizing potential of spermatozoa. J In Vitro Fert Embryo Transf. 1989;6:119–121
  12. Polak B, Daunter B. Osmolarity of human seminal plasma. Andrologia. 1984;16:224–227
  13. Smith R, Vantman D, Ponce J, Escobar J, Lissi E. Total antioxidant capacity of human seminal plasma. Hum Reprod. 1996;11:1655–1660
  14. Ganani E, Powell RL. Transient flow viscometry. J Rheol. 1985;29:931–941
  15. Venables WN, Smith DM, the R Development Core Team. An introduction to R. Bristol, UK: Network Theory, 2002
  16. Dunn OJ, Clark VA. Applied statistics (analysis of variance and regression). New York: John Wiley & Sons; 1974;
  17. Bird RB, Armstrong RC, Hassager O. Dynamics of polymerics liquids, Volume 1 (fluid mechanics). 2nd ed.. New York: John Wiley & Sons; 1987;
  18. Kokini JL, Surmay K. Steady shear viscosity first normal stress difference and recoverable strain in carboxymethyl cellulose, sodium alginate and guar gum. Carbohydr Polym. 1994;23:27–33
  19. Barry BW, Meyer MC. The rheological properties of carbopol gels I. Continuous shear and creep properties of carbopol gels. Int J Pharm. 1979;2:1–25
  20. Barry BW, Meyer MC. The rheological properties of carbopol gels II. Oscillatory properties of carbopol gels. Int J Pharm. 1979;2:27–40
  21. Rossi S, Bonferoni C, Lippoli G, et al.  Influence of mucin type on polymer-mucin rheological interactions. Biomaterials. 1995;16:1073–1079
  22. Dolz M, Herraez M, Gonzalez F, Diez J, Hernandez MJ. Flow behaviour of carbopol-940 hydrogels. The influence of concentration and agitation time. Pharmazie. 1998;53:126–130
  23. Robinson JR. Vaginal formulations (the quest for prolonged effectiveness). In:  Rencher WF editors. Vaginal microbicide formulations workshop. Philadelphia: Lippincott-Raven; 1998;p. 30–37
  24. Carmella CM, Rossi S, Bonferoni MC. A rheological approach to explain the mucoadhesive behaviour of polymer hydrogels. In:  Mathiowitz E editors. Bioadhesive drug delivery systems. New York: Marcel Dekker, Inc; 1999;p. 25–65
  25. Park NA, Irvine TF. Anomalous viscosity-temperature behavior of aqueous carbopol solutions. J Rheol. 1997;41:167–173
  26. Ghannam MT, Esmail MN. Rheological properties of carboxymethyl cellulose. J Appl Polym Sci 1997;64:289–3

PII: S0010-7824(02)00430-4

Contraception
Volume 67, Issue 1 , Pages 57-64 , January 2003