Contraception
Volume 67, Issue 1 , Pages 73-78 , January 2003

A short-term evaluation of semen and accessory sex gland function in phase III trial subjects receiving intravasal contraceptive RISUG

  • S.P. Chaki

      Affiliations

    • Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Mehrauli Road, Munirka, New Delhi 110067, India
    • ,
  • H.C. Das

      Affiliations

    • Family Welfare Centre (Male), Lok Nayak Jay Prakash Hospital, Daryagang, New Delhi 110002, India
    • ,
  • M.M. Misro

      Affiliations

    • Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Mehrauli Road, Munirka, New Delhi 110067, India
    • Corresponding Author InformationCorresponding author. Tel.: +91-11-616-5959; fax: +91-11-610-1623.

Received 29 August 2001 ,Revised 13 September 2002 ,Accepted 18 September 2002.

References 

  1. Guha SK. Contraceptive for use by a male. US patent. 1996; 5488075
  2. Guha SK, Singh G, Anand S, Ansari S, Kumar S, Koul V. Phase I clinical trial of an injectable contraceptive for the male contraception. Contraception. 1993;48:367–375
  3. Guha SK, Singh G, Ansari S, et al.  Phase II clinical trial of a vas deferens injectable contraceptive for the male. Contraception. 1997;56:245–250
  4. World Health Organization. Laboratory manual for the examination of human semen and sperm cervical mucus interaction. 4th ed. New York: Cambridge University Press; 1999;
  5. Roy S, Banerjee A, Pandey HC, Singh G, Kumari GL. Application of seminal germ cell morphology and semen biochemistry in the diagnosis and management of azoospermic subjects. Asian J Androl. 2001;3:55–62
  6. Cooper TG, Yeung CH, Nashan D, Jockenhovel F, Nieschlag E. Improvement in the assessment of human epididymal function by the use of inhibitors in the assay of α-glucosidase in seminal plasma. Int J Androl. 1990;13:297–305
  7. Heite HJ, Wetterauer W. Acid phosphatase in seminal fluid (method of estimation and diagnostic significance). Andrologia. 1992;11:113–122
  8. Rubio C, Gil-Salom M, Simon C, et al.  Incidence of sperm chromosomal abnormalities in a risk population (relationship with sperm quality and ICSI outcome). Hum Reprod. 2001;16:2084–2092
  9. Gopalkrishan K, Padwal V, Meharji PK, Gokral JS, Juneja HS. Poor quality of sperm as it affects repeated early pregnancy loss. Arch Androl. 2000;45:111–117
  10. Sharma U, Chaudhury K, Jagannathan NR, Guha SK. A proton NMR study of the effect of a new intravasal injectable male contraceptive RISUG on seminal plasma metabolites. Reproduction. 2001;122:431–436

PII: S0010-7824(02)00442-0

Contraception
Volume 67, Issue 1 , Pages 73-78 , January 2003

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