Contraception
Volume 74, Issue 1 , Pages 36-41 , July 2006

A systematic review of more than one dose of misoprostol after mifepristone for abortion up to 10 weeks of gestation

  • Maria F. Gallo

      Affiliations

    • Ipas, Research and Evaluation Unit, Chapel Hill, NC 27516, USA
    • Corresponding Author InformationCorresponding reviewer. Tel.: +1 919 960 5716; fax: +1 919 929 7687.
  • ,
  • Susan Cahill

      Affiliations

    • Choice Family Health Care, Kalispell, MT, USA
  • ,
  • Laura Castleman

      Affiliations

    • Ipas, Training and Service Delivery Improvement Unit, Chapel Hill, NC, USA
  • ,
  • Ellen M.H. Mitchell

      Affiliations

    • Ipas, Research and Evaluation Unit, Chapel Hill, NC 27516, USA

Received 10 February 2006 ,Accepted 16 February 2006.

References 

  1. Grimes DA, Creinin MD. Induced abortion: an overview for internists. Ann Intern Med. 2004;140:620–626
  2. Honkanen H, Piaggio G, von Hertzen H, et al. WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. II: side effects and women's perceptions. BJOG. 2004;111:715–725
  3. Trussell J, Ellertson C. Estimating the efficacy of medical abortion. Contraception. 1999;60:119–135
  4. Hedley A, Ellertson C, Trussell J, et al. Accounting for time: insights from a life-table analysis of the efficacy of medical abortion. Am J Obstet Gynecol. 2004;191:1928–1933
  5. von Hertzen H, Honkanen H, Piaggio G, et al. WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. I: efficacy. BJOG. 2003;110:808–818
  6. Honkanen H, Piaggio G, von Hertzen H, et al. WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. BJOG. 2004;111:715–725
  7. Creinin MD, Schwartz JL, Pymar HC, et al. Efficacy of mifepristone followed on the same day by misoprostol for early termination of pregnancy: report of a randomised trial. BJOG. 2001;108:469–473
  8. Hamoda H, Ashok PW, Flett GM, et al. A randomised controlled trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation. BJOG. 2005;112:1102–1108
  9. Schaff EA, Fielding SL, Westhoff C, et al. Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: a randomized trial. JAMA. 2000;284:1948–1953
  10. Schaff EA, Fielding SL, Westhoff C. Randomized trial of oral versus vaginal misoprostol at one day after mifepristone for early medical abortion. Contraception. 2001;64:81–85
  11. Schaff EA, Fielding SL, Westhoff C. Randomized trial of oral versus vaginal misoprostol 2 days after mifepristone 200 mg for abortion up to 63 days of pregnancy. Contraception. 2002;66:247–250
  12. Creinin MD, Fox MC, Teal S, et al. A randomized comparison of misoprostol 6 to 8 hours versus 24 hours after mifepristone for abortion. Obstet Gynecol. 2004;103:851–859
  13. Ashok PW, Templeton A, Wagaarachchi PT, et al. Factors affecting the outcome of early medical abortion: a review of 4132 consecutive cases. BJOG. 2002;109:1281–1289
  14. Aubény E, Chatellier G. A randomized comparison of mifepristone and self-administered oral or vaginal misoprostol for early abortion. Eur J Contracept Reprod Health Care. 2000;5:171–177
  15. Aubény E. A two-stage increase in the dose of misoprostol improves the efficacy of medical abortion with mifepristone and prostaglandins. Eur J Contracept Reprod Health Care. 2001;6:54–55
  16. Basu R, Gundlach T, Tasker M. Mifepristone and misoprostol for medical termination of pregnancy: the effectiveness of a flexible regimen. J Fam Plann Reprod Health Care. 2003;29:139–141
  17. Hamoda H, Ashok PW, Dow J, et al. A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation. Contraception. 2003;68:335–338
  18. Aubény E, Peyron R, Turpin CL, et al. Termination of early pregnancy (up to 63 days of amenorrhea) with mifepristone and increasing doses of misoprostol. Int J Fertil Menopausal Stud. 1995;40:85–91
  19. Fiala C, Winikoff B, Helstrom L, et al. Acceptability of home-use of misoprostol in medical abortion. Contraception. 2004;70:387–392
  20. Fox MC, Creinin MD, Harwood B. Mifepristone and vaginal misoprostol on the same day for abortion from 50 to 63 days' gestation. Contraception. 2002;66:225–229
  21. Guengant JP, Bangou J, Elul B, et al. Mifepristone–misoprostol medical abortion: home administration of misoprostol in Guadeloupe. Contraception. 1999;60:167–172
  22. Murthy AS, Creinin MD, Harwood B, et al. A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation. Contraception. 2005;71:333–336
  23. Peyron R, Aubény E, Targosz V, et al. Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol. N Engl J Med. 1993;328:1509–1513
  24. Prine L, Lesnewski R, Berley N, et al. Medical abortion in family practice: a case series. J Am Board Fam Pract. 2003;16:290–295
  25. Pymar HC, Creinin MD, Schwartz JL. Mifepristone followed on the same day by vaginal misoprostol for early abortion. Contraception. 2001;64:87–92
  26. Schaff EA, Stadalius LS, Eisinger SH, et al. Vaginal misoprostol administered at home after mifepristone (RU486) for abortion. J Fam Pract. 1997;44:353–360
  27. Schaff EA, Eisinger SH, Stadalius LS, et al. Low-dose mifepristone 200 mg and vaginal misoprostol for abortion. Contraception. 1999;59:1–6
  28. Schaff EA, Fielding SL, Eisinger SH, et al. Low-dose mifepristone followed by vaginal misoprostol at 48 hours for abortion up to 63 days. Contraception. 2000;61:41–46
  29. Schreiber CA, Creinin MD, Harwood B, et al. A pilot study of mifepristone and misoprostol administered at the same time for abortion in women with gestation from 50 to 63 days. Contraception. 2005;71:447–450
  30. Tang OS, Gao PP, Cheng L, et al. Pilot study on the use of a two-week course of oral misoprostol in patients after termination of pregnancy with mifepristone and misoprostol. Contraception. 1998;57:89–91
  31. Weeks AD, Stewart P. The use of low dose mifepristone and vaginal misoprostol for first trimester termination of pregnancy. Br J Fam Plann. 1995;21:85–86

PII: S0010-7824(06)00083-7

doi: 10.1016/j.contraception.2006.02.011

Contraception
Volume 74, Issue 1 , Pages 36-41 , July 2006