Contraception
Volume 74, Issue 6 , Pages 451-457 , December 2006

Efficacy, acceptability and tolerability of the combined contraceptive ring, NuvaRing, compared with an oral contraceptive containing 30 μg of ethinyl estradiol and 3 mg of drospirenone

  • Hans-Joachim Ahrendt

      Affiliations

    • Halberstädter Straβe 122, D-39112 Magdeburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 391 60 19 60; fax: +49 391 60 40 74.
    • ,
  • Israel Nisand

      Affiliations

    • Department of Gynaecology and Obstetrics, Hautepierre Hospital, 67098 Strasbourg Cédex, France
    • ,
  • Carlo Bastianelli

      Affiliations

    • Department of Gynaecolgy, Perinatology and Childcare, University of Rome La Sapienza, 00161 Rome, Italy
    • ,
  • Maria Angeles Gómez

      Affiliations

    • Family Planning Centre, Valencian Health Agency, 03013 Alicante, Spain
    • ,
  • Kristina Gemzell-Danielsson

      Affiliations

    • Division for Obstetrics and Gynaecology, Department of Woman and Child Health, Karolinska Institute, S-171 76 Stockholm, Sweden
    • ,
  • Wolfgang Urdl

      Affiliations

    • Department of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria
    • ,
  • Birgit Karskov

      Affiliations

    • Værløse Lægehus, Bymidten 39, 1, 3500 Værløse, Dk Denmark
    • ,
  • Luc Oeyen

      Affiliations

    • Department of Gynecology, Saint Vincent Hospital, St. Vincentiusstraat 20, 2018 Antwerpen, Belgium
    • ,
  • Johannes Bitzer

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Basel, CH-4031 Basel, Switzerland
    • ,
  • Geert Page

      Affiliations

    • Department of Obstetrics and Gynaecology, Gasthuisstraat 59, 8970 Poperinge, Belgium
    • ,
  • Ian Milsom

      Affiliations

    • Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, SE-416 85 Göteborg, Sweden

Received 10 February 2006 ,Revised 25 July 2006 ,Accepted 26 July 2006.

References 

  1. Rosenberg MJ, Waugh MS. Oral contraceptive discontinuation: a prospective evaluation of frequency and reasons. Am J Obstet Gynecol. 1998;179:577–582
  2. Rosenberg M.J., Waugh M.S., Burnhill M.S. Compliance, counseling and satisfaction with oral contraceptives: a prospective evaluation. Fam Plann Perspect. 1998;30:89-92,104.
  3. Rosenberg M, Waugh MS. Causes and consequences of oral contraceptive noncompliance. Am J Obstet Gynecol. 1999;180:S276–S279
  4. Burkman RT. Oral contraceptives: current status. Clin Obstet Gynecol. 2001;44:62–72
  5. Timmer CJ, Mulders TM. Pharmacokinetics of etonogestrel and ethinylestradiol released from a combined contraceptive vaginal ring. Clin Pharmacokinet. 2000;39:233–242
  6. Roumen FJ, Apter D, Mulders TM, Dieben TO. Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol. Hum Reprod. 2001;16:469–475
  7. Dieben TO, Roumen FJ, Apter D. Efficacy, cycle control, and user acceptability of a novel combined contraceptive vaginal ring. Obstet Gynecol. 2002;100:585–593
  8. Oddsson K, Leifels-Fischer B, de Melo NR, et al. Efficacy and safety of a contraceptive vaginal ring (NuvaRing) compared with a combined oral contraceptive: a 1-year randomized trial. Contraception. 2005;71:176–182
  9. Bjarnadottir RI, Tuppurainen M, Killick SR. Comparison of cycle control with a combined contraceptive vaginal ring and oral levonorgestrel/ethinyl estradiol. Am J Obstet Gynecol. 2002;186:389–395
  10. Ahrendt H-J, Nap MA, Marintcheva-Petrova MZ. Contraceptive efficacy with NuvaRing vs two combined oral contraceptives - data from a pooled analysis. Eur J Contraception Reprod Health Care. 2006;11(Suppl 1):59
  11. Urdl W, Apter D, Alperstein A, Koll P, et al. Contraceptive efficacy, compliance and beyond: factors related to satisfaction with once-weekly transdermal compared with oral contraception. Eur J Obstet Gynecol Reprod Biol. 2005;121:202–210
  12. Archer DF, Cullins V, Creasy GW, Fisher AC. The impact of improved compliance with a weekly contraceptive transdermal system (Ortho Evra) on contraceptive efficacy. Contraception. 2004;69:189–195
  13. Novak A, de la Loge C, Abetz L, van der Meulen EA. The combined contraceptive vaginal ring, NuvaRing®: an international study of user acceptability. Contraception. 2003;67:187–194
  14. Rosenberg MJ, Meyers A, Roy V. Efficacy, cycle control, and side effects of low- and lower-dose oral contraceptives: a randomized trial of 20 micrograms and 35 micrograms estrogen preparations. Contraception. 1999;60:321–329
  15. Rosenberg MJ, Waugh MS, Meehan TE. Use and misuse of oral contraceptives: risk indicators for poor pill-taking and discontinuation. Contraception. 1995;51:283–288

PII: S0010-7824(06)00308-8

doi: 10.1016/j.contraception.2006.07.004

Contraception
Volume 74, Issue 6 , Pages 451-457 , December 2006

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