Contraception
Volume 75, Issue 1 , Pages 23-26 , January 2007

Endometrial histology following 1 year of a continuous daily regimen of levonorgestrel 90 μg/ethinyl estradiol 20 μg

  • Julia V. Johnson

      Affiliations

    • Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, VT 05401, USA
    • ,
  • Gary S. Grubb

      Affiliations

    • Women's Health, Clinical Research/Development, Wyeth Research, 500 Arcola Road E-5, Collegeville, PA 19426, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 484 865 5745; fax: +1 484 865 9179.
    • ,
  • Ginger D. Constantine

      Affiliations

    • Women's Health, Clinical Research/Development, Wyeth Research, 500 Arcola Road E-5, Collegeville, PA 19426, USA

Received 11 May 2006 ,Accepted 17 July 2006.

References 

  1. The ESHRE Capri Workshop Group. Ovarian and endometrial function during hormonal contraception. Hum Reprod. 2001;16:1527–1535
  2. Coenen CM, Hollanders JM, Rolland R, Spielmann D, Bulten J. The effects of a low-dose gestodene-containing oral contraceptive on endometrial histology in healthy women. Eur J Contracept Reprod Health Care. 1996;1:325–329
  3. Archer DF. Endometrial histology during use of a low-dose estrogen–desogestrel oral contraceptive with a reduced hormone-free interval. Contraception. 1999;60:151–154
  4. Oosterbaan HP. An open-label study of the effects of a 24-day regimen of gestodene 60 μg/ethinylestradiol 15 μg on endometrial histological findings in healthy women. Eur J Contracept Reprod Health Care. 1999;4(Suppl 2):3–8
  5. Lüdicke F, Johannisson E, Helmerhorst FM, Campana A, Foidart J, Heithecker R. Effect of a combined oral contraceptive containing 3 mg of drospirenone and 30 μg of ethinyl estradiol on the human endometrium. Fertil Steril. 2001;76:102–107
  6. Anderson FD, Hait H, Hsiu J, Thompson-Graves AL, Wilborn WH, Williams RF. Endometrial microstructure after long-term use of a 91-day extended-cycle oral contraceptive regimen. Contraception. 2005;71:55–59
  7. Miller L, Hughes JP. Continuous combination oral contraceptive pills to eliminate withdrawal bleeding: a randomized trial. Obstet Gynecol. 2003;101:653–661
  8. Archer DF, Jensen JT, Johnson JV, Borisute H, Grubb GS, Constantine G. Evaluation of a continuous regimen of levonorgestrel/ethinyl estradiol: phase 3 study results. Contraception [in press].
  9. In:  Kurman RJ editors. Blaustein's pathology of the female genital tract. 5th ed.. New York: Springer; 2002;
  10. Kaunitz AM. Long-acting injectable contraception with depot medroxyprogesterone acetate. Am J Obstet Gynecol. 1994;170:1543–1549

PII: S0010-7824(06)00309-X

doi: 10.1016/j.contraception.2006.07.009

Contraception
Volume 75, Issue 1 , Pages 23-26 , January 2007

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