Contraception
Volume 76, Issue 6 , Pages 439-443, December 2007

Vaginal yeast adherence to the combined contraceptive vaginal ring (CCVR)☆

  • Daiane Pereira Camacho

      Affiliations

    • Department of Clinical Analysis, Division of Medical Mycology, Teaching and Research in Clinical Analysis Laboratory, State University of Maringá, 87020-900 Paraná, Brazil
    • ,
  • Márcia E.L. Consolaro

      Affiliations

    • Department of Clinical Analysis, Division of Clinical Cytology, Teaching and Research in Clinical Analysis Laboratory, State University of Maringá, 87020-900 Paraná, Brazil
    • ,
  • Eliana Valéria Patussi

      Affiliations

    • Department of Clinical Analysis, Division of Medical Mycology, Teaching and Research in Clinical Analysis Laboratory, State University of Maringá, 87020-900 Paraná, Brazil
    • ,
  • Lucélia Donatti

      Affiliations

    • Department of Cellular Biology, Federal University of Paraná, 81531-900 Curitiba, Brazil
    • ,
  • André Gasparetto

      Affiliations

    • Department of Dentistry, State University of Maringá, 87020-900 Paraná, Brazil
    • ,
  • Terezinha I.E. Svidzinski

      Affiliations

    • Department of Clinical Analysis, Division of Medical Mycology, Teaching and Research in Clinical Analysis Laboratory, State University of Maringá, 87020-900 Paraná, Brazil
    • Corresponding Author InformationCorresponding author. Departamento de Análises Clínicas — DAC, Laboratório de Ensino e Pesquisa em Análises Clínicas — LEPAC, Universidade Estadual de Maringá, Avenida Colombo, 5790, Bloco J90, sala 11, Maringá, Paraná, CEP: 87020-900, Brazil. Tel.: +55 44 3261 4809; fax: +55 3261 4860.

Received 5 February 2007; received in revised form 4 June 2007; accepted 13 July 2007. published online 22 October 2007.

Abstract 

Background

The purpose of this study was to evaluate the in vitro adherence of different yeasts, isolated from vaginal exudates of patients with vulvovaginal candidiasis (VVC), to the combined contraceptive vaginal ring — NuvaRing®.

Study Design

Four isolates of Candida sp. and one isolate of Saccharomyces cerevisiae were used. Adherence assays were carried out through colony-forming units per milliliter (CFU/mL), radiolabeled quantification and scanning electron microscopy (SEM) of the ring, and the cell surface hydrophobicity (CSH) of the yeasts was determined.

Results

All the yeasts were capable of adhering to the vaginal ring, as determined by CFU/mL and in the radiolabeled assay. CSH was compatible with the adherence by CFU/mL.

Conclusion

SEM proved the adhesion, which was different between Candida albicans and C. tropicalis. The adherence of the tested yeasts to the ring could potentially facilitate the development of VVC and recurrent VVC in susceptible patients using this contraceptive method.

Keywords: NuvaRing®, Adherence, Candida sp., Vulvovaginal candidiasis

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☆ This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior and Conselho Nacional de Desenvolvimento Científico e Tecnológico (No. 474542/2003-3).

PII: S0010-7824(07)00377-0

doi:10.1016/j.contraception.2007.07.012

Contraception
Volume 76, Issue 6 , Pages 439-443, December 2007

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