Contraception
Volume 77, Issue 3 , Pages 195-204 , March 2008

Vaginal distribution of Replens® and K-Y® Jelly using three imaging techniques

  • Christine K. Mauck

      Affiliations

    • CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 703 276 3912; fax: +1 703 524 4770.
    • ,
  • David Katz

      Affiliations

    • Departments of Biomedical Engineering and Obstetrics and Gynecology, Duke University, Durham, NC 27708, USA
    • ,
  • Erik P. Sandefer

      Affiliations

    • Scintipharma, Inc., 2201 Regency Road, Suite 403, Lexington, KY 40503, USA
    • ,
  • Marlina D. Nasution

      Affiliations

    • Family Health International, Research Triangle Park, PO Box 13950, NC 27709, USA
    • ,
  • Marcus Henderson

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, NC 27709, USA
    • ,
  • George A. Digenis

      Affiliations

    • College of Pharmacy, University of Kentucky, Lexington, KY 405036, USA
    • ,
  • Irene Su

      Affiliations

    • Penn Fertility Care, Department of Obstetrics and Gynecology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    • ,
  • Richard Page

      Affiliations

    • Scintipharma, Inc., 2201 Regency Road, Suite 403, Lexington, KY 40503, USA
    • ,
  • Kurt Barnhart

      Affiliations

    • Penn Fertility Care, Department of Obstetrics and Gynecology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA

Received 2 August 2007 ,Revised 15 October 2007 ,Accepted 1 November 2007.

References 

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  2. MDS Working Groups. The microbicide development strategy. Silver Spring: Alliance for Microbicide Development; 2006;
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  5. Digenis GA. Toxicology studies: Utilization of short-lived radionuclides in the assessment of the safety and deposition of novel products. In:  Zatuchni GI,  Labbok MH,  Sciarra JJ editor. Research Frontiers. Fertility Regulation. New York: Harper and Row Publishers; 1980;p. 23–31
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  7. Brown J, Hooper G, Kenyon CJ, et al. Spreading and retention of vaginal formulations in post-menopausal women as assessed by gamma scintigraphy. Pharmaceut Res. 1997;14:1073–1078
  8. Barnhart KT, Pretorius ES, Stolpen A, Malamud D. Distribution of topical medication in the human vagina as imaged by MRI. Fertil Steril. 2001;76:189–195
  9. Barnhart KT, Pretorius ES, Timbers K, Shera D, Shabbout M, Malamud D. In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time, and simulated intercourse. Contraception. 2004;70:498–505
  10. Barnhart KT, Pretorius ES, Shaunik A, Timbers KT, Nasution M, Mauck C. Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL). Contraception. 2005;72:65–70
  11. Barnhart KT, Pretorius ES, Timbers K, Shera D, Shabbout M, Malamud D. Distribution of a 3.5-mL (1.0%) C31G vaginal gel using magnetic resonance imaging. Contraception. 2005;71:357–361
  12. Barnhart KT, Pretorius ES, Shera D, Shabbout MS, Shaunik A. The optimal analysis of MRI data to quantify the distribution of a microbicide. Contraception. 2005;73:82–87
  13. Kieweg SL, Geonnotti AR, Katz DF. Gravity-induced coating flows of vaginal gel formulations: in vitro experimental analysis. J Pharm Sci. 2004;93:2941–2952
  14. Kieweg S, Katz D. Interpreting properties of microbicide drug delivery gels: analyzing deployment due to squeezing. J Pharma Sci. 2007;96:835–850
  15. Lai BE, Xie YQ, Lavine ML, Szeri AJ, Owen DH, Katz DF. Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheology and coating flow. J Pharma Sci. 2007;[electronic publication ahead of print]
  16. Owen DH, Peters JJ, Katz DF. Rheological properties of contraceptive gels. Contraception. 2000;62:321–326
  17. Owen DH, Peters JJ, Katz DF. Comparison of the rheological properties of Advantage-s and Replens. Contraception. 2001;64:393–396
  18. Owen DH, Peters JJ, Lavine ML, Katz DF. Effect of temperature and pH on contraceptive gel viscosity. Contraception. 2003;67:57–64
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  21. Barnhart KT, Pretorius ES, Stolpen A, Malamud D. Distribution of topical medication in the human vagina as imaged by MRI. Fertil Steril. 2001;76:189–195
  22. Barnhart KT, Pretorius ES, Malamud D. Lesson learned and dispelled myths: 3-D imaging of the human vagina. Fertil Steril. 2004;81:1383–1384
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  24. Barnhart KT, Stolpen A, Pretorius ES, Malamud D. Distribution of a spermicide containing nonoxynol-9 in the vaginal canal and the upper female reproductive tract. Hum Reprod. 2001;16:1151–1154
  25. Barnhart KT, Pretorius ES, Marunich R, Hummel A. Vaginal distribution of miconazole nitrate suspension from administration of a single vaginal insert. J Reprod Med. 2004;49:83–88
  26. Menon S, Izquierdo A, Rosen M, Hummel A, Barnhart KT. The effect of ambulation on vaginal distribution of miconazole nitrate vaginal Ovule® insert (1200 mg). J Womens Health. 2007;16:703–706
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  28. Kunz G, Beil D, Deininger H, Wildt L, Leyendecker G. The dynamics of rapid sperm transport through the female genital tract: evidence from vaginal sonography of uterine peristalsis and hysterosalpingoscintigraphy. Hum Reprod. 1996;11:627–632
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☆ Support for this study was provided by the United States Agency for International Development through CSA-01-295. The views expressed in this paper do not necessarily reflect those of USAID.

PII: S0010-7824(07)00517-3

doi: 10.1016/j.contraception.2007.11.016

Contraception
Volume 77, Issue 3 , Pages 195-204 , March 2008

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