Prevalence of psychiatric disorders and premenstrual dysphoric symptoms in patients with experience of adverse mood during treatment with combined oral contraceptives

Segebladh, Birgitta; Borgström, Anna; Odlind, Viveca; Bixo, Marie; Sundström-Poromaa, Inger

doi:10.1016/j.contraception.2008.08.001

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Volume 79, Issue 1 , Pages 50-55, January 2009

Prevalence of psychiatric disorders and premenstrual dysphoric symptoms in patients with experience of adverse mood during treatment with combined oral contraceptives

Birgitta Segebladh
- Department of Women's and Children's Health, University Hospital, Uppsala University, SE-751 85 Uppsala, Sweden
- Corresponding author. Tel.: +46 18 611 57 64; fax: + 46 18 55 97 75.
- Authors B. Segebladh and A. Borgström equally share first authorship of this study.
Anna Borgström
- Department of Women's and Children's Health, University Hospital, Uppsala University, SE-751 85 Uppsala, Sweden
- Authors B. Segebladh and A. Borgström equally share first authorship of this study.
Viveca Odlind
- Department of Women's and Children's Health, University Hospital, Uppsala University, SE-751 85 Uppsala, Sweden
- Medical Products Agency, 751 03 Uppsala, Sweden
Marie Bixo
- Department of Clinical Science, Obstetrics and Gynecology, Umeå University, 901 85 Umeå, Sweden
Inger Sundström-Poromaa
- Department of Women's and Children's Health, University Hospital, Uppsala University, SE-751 85 Uppsala, Sweden

Received 27 March 2008; received in revised form 1 August 2008; accepted 1 August 2008. published online 15 September 2008.

Abstract

Background

Negative mood symptoms remain one of the major reasons for discontinuation of combined oral contraceptive pills (COCs). The primary aim of this study was to compare the prevalence of mood and anxiety disorders in women with different experience of COCs.

Study Design

Thirty women currently on COCs with no report of adverse mood symptoms, 28 women currently on COCs and experiencing mood-related side effects, 33 women who had discontinued COC use due to adverse mood effects and 27 women who had discontinued COC use for reasons other than adverse mood symptoms were included. Ongoing psychiatric disorders were evaluated by a structured psychiatric interview and prevalence rates of premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) were assessed by daily prospective ratings on the Cyclicity Diagnoser scale.

Results

Women with ongoing or past experience of COC-induced adverse mood, more often suffered from mood disorders than women with no reports of adverse mood while on COC. The prevalence of prospectively defined PMS or PMDD did not differ between prior users with positive or negative experience. Women who had discontinued COC use due to adverse mood symptoms more often had had a legal abortion in the past.