Contraception
Volume 79, Issue 2 , Pages 117-121 , February 2009

Evidence that in healthy young women, a six-cycle treatment with oral contraceptive containing 30 mcg of ethinylestradiol plus 2 mg of chlormadinone acetate reduces fat mass

Received 18 April 2008 ,Revised 26 August 2008 ,Accepted 26 August 2008.

References 

  1. Walters WAW, Lim YL. Haemodynamic changes in women taking oral contraceptives. J Obstet Gynaecol Br Commonw. 1970;77:1088–1099
  2. Crane MG, Harris JJ. Effect of oestrogens and gestagens on exchangeable sodium. In:  Fregly MJ,  Fregly MS editor. Oral contraceptives and high blood pressure. Gainesville (FL): Dolphin Press; 1974;p. 159–169
  3. Oelkers WK. Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure. Steroids. 1996;61:166–171
  4. Cagnacci A, Zanin R, Cannoletta M, Generali M, Caretto S, Volpe A. Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures. Fertil Steril. 2007;88:1603–1608
  5. Cagnacci A, De Toni A, Caretto S, et al. Cyclic progestin administration increases energy expenditure and decreases body fat mass in perimenopausal women. Menopause. 2006;13:197–201
  6. Poehlman ET. Menopause, energy expenditure, and body composition. Acta Obstet Gynecol Scand. 2002;81:603–611
  7. Arciero PJ, Goran MI, Poehlman ET. Resting metabolic rate is lower in women than in men. J Appl Physiol. 1993;75:2514–2520
  8. Buchholz AC, Rafii M, Pencharz PB. Is resting metabolic rate different between men and women?. Br J Nutr. 2001;86:641–646
  9. Rosenberg MJ, Waugh MS. Oral contraceptive discontinuation: a prospective evaluation of frequency and reasons. Am J Obstet Gynecol. 1998;179:577–582
  10. Rosenberg M. Weight change with oral contraceptive use and during the menstrual cycle. Contraception. 1998;58:345–349
  11. Gallo MF, Grimes DA, Schulz KF, Helmerhorst FM. Combination estrogen-progestin contraceptives and body weight: systematic review of randomized controlled trials. Obstet Gynecol. 2004;103:359–373
  12. Kyle UG, Bosaeus I, De Lorenzo AD, et al. Bioelectrical impedance analysis — part II: utilization in clinical practice. Clin Nutr. 2004;23:1430–1453
  13. Martinoli R, Mohamed EI, Maiolo C, et al. Total body fluid estimation using bioelectrical impedance: a meta-analysis of the data available in the literature. Acta Diabetol. 2003;40(Suppl 1):S203`–S206`
  14. Gudivaka R, Schoeller DA, Kushner RF, Bolt MJ. Single and multifrequency model for bioelectrical impedance analysis of body water compartments. J Appl Physiol. 1999;87:1087–1096
  15. Curran MP, Wagstaff AJ. Ethinylestradiol/chlormadinone acetate. Drugs. 2004;64:751–760
  16. Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2003;46(Suppl 1):S7–S16
  17. Raudrant D, Rabe T. Progestogens with antiandrogenic properties. Drugs. 2003;63:463–492
  18. Fruzzetti F, Lello S, Lazzarini V, et al. The oral contraceptive containing 30 microg of ethinylestradiol plus 3 mg of drospirenone is able to antagonize the increase of extracellular fluid occurring in healthy young women during the luteal phase of the menstrual cycle: an observational study. Contraception. 2007;75:199–203
  19. Lello S, Vittori G, Paoletti AM, Sorge R, Guardianelli F, Melis GB. Effects on body weight and body composition of a low-dose oral estroprogestin containing ethinyl estradiol 20 microg plus levonorgestrel 100 microg. Gynecol Endocrinol. 2007;23:632–637
  20. Thomas L, Krebs CJ. In: A review of statistical power analysis software. Vol. 78:New York: Bulletin of the Ecological Society of America; 1997;p. 128–139
  21. Reubinoff BE, Grubstein A, Meirow D, Berry E, Schenker JG, Brzezinski A. Effects of low-dose estrogen oral contraceptives on weight, body composition, and fat distribution in young women. Fertil Steril. 1995;63:516–521
  22. de Melo NR, Aldrighi JM, Faggion D, et al. A prospective open-label study to evaluate the effects of the oral contraceptive Harmonet (gestodene75/EE20) on body fat. Contraception. 2004;70:65–71
  23. Machado RB, Tachotti F, Cavenague G, Maia E. Effects of two different oral contraceptives on total body water: a randomized study. Contraception. 2006;73:344–347
  24. Hu FB, Manson JE, Stampfer MJ, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med. 2001;345:790–797
  25. Key TJ, Appleby PN, Reeves GK, et al. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst. 2003;95:1218–1226

PII: S0010-7824(08)00429-0

doi: 10.1016/j.contraception.2008.08.007

Contraception
Volume 79, Issue 2 , Pages 117-121 , February 2009