Contraception
Volume 79, Issue 2 , Pages 84-90 , February 2009

Two-pill regimens of misoprostol after mifepristone medical abortion through 63 days' gestational age: a randomized controlled trial of sublingual and oral misoprostol

  • Sheila Raghavan

      Affiliations

    • Gynuity Health Projects, New York, NY 10010, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 448 1230; fax: +1 212 448 1260.
    • ,
  • Rodica Comendant

      Affiliations

    • State Medical and Pharmacy University, Municipal Clinical Hospital No. 1, Chisinau 2001, Republic of Moldova
    • ,
  • Irena Digol

      Affiliations

    • State Medical and Pharmacy University, Municipal Clinical Hospital No. 1, Chisinau 2001, Republic of Moldova
    • ,
  • Sergiu Ungureanu

      Affiliations

    • State Medical and Pharmacy University, Municipal Clinical Hospital No. 1, Chisinau 2001, Republic of Moldova
    • ,
  • Valentin Friptu

      Affiliations

    • State Medical and Pharmacy University, Municipal Clinical Hospital No. 1, Chisinau 2001, Republic of Moldova
    • ,
  • Hillary Bracken

      Affiliations

    • Gynuity Health Projects, New York, NY 10010, USA
    • ,
  • Beverly Winikoff

      Affiliations

    • Gynuity Health Projects, New York, NY 10010, USA

Received 27 May 2008 ,Revised 2 September 2008 ,Accepted 2 September 2008.

References 

  1. Winikoff B, Sivin I, Coyaji KJ, et al. Safety, efficacy and acceptability of medical abortion in China, Cuba, and India: a comparative trial of mifepristone-misoprostol versus surgical abortion. Am J Obstet Gynecol. 1997;176:431–437
  2. Winikoff B, Ellertson C, Elul B, Sivin I. Acceptability and feasibility of early pregnancy termination by mifepristone-misoprostol. Arch Fam Med. 1998;7:360–366
  3. Peyron R, Aubeny E, Targosz V, et al. Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol. N Engl J Med. 1993;328:1509–1513
  4. Elul B, Hajri S, Ngoc NN, et al. Can women in less-developed countries use a simplified medical abortion regimen?. Lancet. 2001;357:1402–1405
  5. World Health Organization Task Force on Post-ovulatory Methods of Fertility Regulation . Comparison of two doses of mifepristone in combination with misoprostol for early medical abortion: a randomized trial. BJOG. 2000;107:524–530
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  10. Tang OS, Xu J, Cheng L, Lee SW, Ho PC. Pilot study on the use of sublingual misoprostol with mifepristone in termination of first trimester pregnancy up to 9 weeks gestation. Hum Reprod. 2002;17:1738–1740
  11. Schaff E, Fielding S, Elsinger SH, Stadalius LS, Fuller L. Low-dose mifepristone followed by vaginal misoprostol at 48 hours for abortion up to 63 days. Contraception. 2000;61:46–61
  12. Singh KC, Ummat S, Rajaram S, Goel N. First trimester abortion with mifepristone and three doses of sublingual misoprostol: a pilot study. Aust N Z J Obstet Gynaecol. 2005;45:495–498
  13. Schaff EA, Fielding SL, Westhoff C, et al. Vaginal misoprostol administered 1,2, or 3 days after mifepristone for early medical abortion: a randomized trial. JAMA. 2000;284:1948–1953
  14. Middleton T, Schaff E, Fielding SL, et al. Randomized trial of mifepristone and buccal or vaginal misoprostol for abortion through 56 days of last menstrual period. Contraception. 2005;72:328–332
  15. von Hertzen H, Honkanen H, Piaggio G, et al. WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. BJOG. 2003;110:808–818
  16. Creinin MD, Schreiber CA, Bednarek P, et al. Mifepristone and misoprostol administered simultaneously versus 24 hours apart for abortion: a randomized controlled trial. Obstet Gynecol. 2007;109:885–894
  17. Schaff EA, Fielding SL, Westhoff C. Randomized trial of oral versus vaginal misoprostol 2 days after mifepristone 200 mcg for abortion up to 63 days of pregnancy. Contraception. 2002;66:247–250
  18. Ngoc NN, Nhan VQ, Blum J, et al. Is home-based administration of prostaglandin safe and feasible for medical abortion? Results from a multisite study in Vietnam. BJOG. 2004;111:814–819
  19. Schaff EA, Fielding SL, Westhoff C. Randomized trial of oral versus vaginal misoprostol at one day after mifepristone for early medical abortion. Contraception. 2001;64:81–85
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  24. Hamoda H, Ashok PW, Flett GM, Templeton A. A randomized controlled trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation. BJOG. 2005;112:1102–1108
  25. Tang OS, Schweer H, Seyberth HW, Lee SW, Ho PC. Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod. 2002;10:332–336
  26. Tang OS, Chan CC, Ng EH, Lee SW, Ho PC. A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misoprostol for medical abortions of less than 9 weeks gestation. Hum Reprod. 2003;18:2315–2318
  27. Hamoda H, Ashok PW, Dow J, Flett GM, Templeton A. A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation. Contraception. 2003;68:335–338
  28. Mundle S, Elul B, Anand A, Kalyanwala S, Ughade S. Increasing access to safe abortion services in rural India: experiences with medical abortion in a primary health center. Contraception. 2007;76:66–70
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PII: S0010-7824(08)00451-4

doi: 10.1016/j.contraception.2008.09.001

Contraception
Volume 79, Issue 2 , Pages 84-90 , February 2009

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