Contraception
Volume 80, Issue 1 , Pages 34-39 , July 2009

Route of administration of contraceptives containing desogestrel/etonorgestrel and insulin sensitivity: a prospective randomized study

Received 17 September 2008 ,Revised 22 January 2009 ,Accepted 26 January 2009.

References 

  1. De Fronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabet Care. 1991;14:173–194
  2. Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities. The role of insulin resistance and the sympathoadrenal system. N Engl J Med. 1996;334:375–381
  3. Després JP, Lamarche B, Mauriége P, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 1996;334:952–957
  4. De Pirro R, Forte F, Bertoli A, Greco AV, Lauro R. Changes in insulin receptors during oral contraception. J Clin Endocrinol Metab. 1981;52:29–33
  5. Kasdorf G, Kalkhoff RK. Prospective studies of insulin sensitivity in normal women receiving oral contraceptive agents. J Clin Endocrinol Metab. 1988;66:846–852
  6. Skouby SO, Andersen O, Saurberey N. Oral contraception and insulin sensitivity: in vivo assessment in normal women and women with previous gestational diabetes. J Clin Endocrinol Metab. 1987;64:519–523
  7. Godsland IF, Walton C, Felton C. Insulin resistance, secretion, and metabolism in users of oral contraceptives. J Clin Endocrinol Metab. 1992;74:64–70
  8. Gaspard UJ, Demeyer F, Jaminet CB, Scheen AJ, Lefebvre PJ. Influence of two low dose oral contraceptives containing ethinylestradiol (20 mcg) and desogestrel or gestodene on carbohydrate metabolism during 1 year of use. Gynecol Endocrinol. 1996;10(Suppl 1):179–181
  9. Petersen KR, Christiansen E, Madsbad S, Skouby SO, Andersen LF, Jespersen J. Metabolic and fibrinolytic response to changed insulin sensitivity in users of oral contraceptives. Contraception. 1999;60:337–344
  10. Cagnacci A, Paoletti AM, Renzi A, et al. Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptive containing cyproterone acetate or desogestrel. J Clin Endocrinol Metab. 2003;88:3621–3625
  11. Mulders TMT, Dieben TOM. Use of novel combined contraceptive vaginal ring NuvaRing for ovulation inhibition. Fertil Steril. 2001;75:865–870
  12. Dieben TOM, Roumen FJME, Apter D. Efficacy, cycle control, and user acceptability of a novel combined contraceptive vaginal ring. Obstet Gynecol. 2002;100:585–593
  13. Killick S. Complete and robust ovulation inhibition with NuvaRing. Eur J Contracept Reprod Health Care. 2002;7(Suppl 2):19–24
  14. Timmer CJ, Mulders TMT. Pharmacokinetics of etonogestrel and ethinyl estradiol released from a combined contraceptive vaginal ring. Clin Pharmacokinet. 2000;39:233–242
  15. Van den Heuvel MV, van Bragt AJM, Alnabawy AKM, Kaptein MCJ. Comparison of ethinylestradiol pharmacokinetics in three hormonal contraceptive formulation: the vaginal ring, the transdermal patch and an oral contraceptive. Contraception. 2005;72:168–174
  16. Welch S, Gebhart SSP, Bergman RN. Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab. 1990;71:1508–1518
  17. American Diabetes Association Consensus Development Conference on Insulin Resistance 1998. Diabetes Care. 1998;21:310–314
  18. Cagnacci A, Arangino S, Renzi A, Cagnacci P, Volpe A. Insulin sensitivity in women: a comparison among values derived from intravenous glucose tolerance tests with different sampling frequency, oral glucose tolerance test or fasting. Eur J Endocrinol. 2001;145:281–287
  19. Bonora E, Zavaroni I, Coscelli C, Butturini U. Decreased hepatic insulin extraction in subject with mild glucose intolerance. Metabolism. 1983;32:438–446
  20. Duijkers I, Killick S, Bigrigg A, Dieben TO. A comparative study on the effects of a contraceptive vaginal ring NuvaRing and an oral contraceptive on carbohydrate metabolism and adrenal and thyroid function. Eur J Contracept Reprod Health Care. 2004;9:131–140
  21. Helkind-Hirsch KE, Sherman LD, Malinak R. Hormone replacement therapy alters insulin sensitivity in young women with premature ovarian failure. J Clin Endocrinol Metab. 1993;76:472–475
  22. Lindheim SR, Presser SC, Ditkoff EC, ViJod MA, Stanczyk FZ, Lobo RA. A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin. Fertil Steril. 1993;60:664–667
  23. Verhoven CH, Gloudemans RH, Peeters PA, et al. Excretion and metabolism of desogestrel in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2001;78:471–480
  24. Cagnacci A, Tirelli A, Cannoletta M, Pirillo D, Volpe A. Effect on insulin sensitivity of Implanon vs. GnRH agonist in women with endometriosis. Contraception. 2005;72:443–446
  25. Tuppurainen M, Klimscheffskij R, Venhola M, Dieben TOM. The combined contraceptive vaginal ring (Nuvaring) and lipid metabolism: a comparative study. Contraception. 2004;69:389–394

☆ This study was supported by unrestricted funds from the Department of Obstetrics, Gynecology and Pediatrics of the University of Modena.

PII: S0010-7824(09)00033-X

doi: 10.1016/j.contraception.2009.01.012

Contraception
Volume 80, Issue 1 , Pages 34-39 , July 2009

Article Tools

* Image Usage & Resolution