Contraception
Volume 81, Issue 1 , Pages 35-40 , January 2010

Oral contraceptive use and bone density in adolescent and young adult women

  • Delia Scholes

      Affiliations

    • Group Health Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 206 287 2888; fax: +1 206 287 2871.
    • ,
  • Laura Ichikawa

      Affiliations

    • Group Health Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    • ,
  • Andrea Z. LaCroix

      Affiliations

    • Group Health Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    • Women's Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    • ,
  • Leslie Spangler

      Affiliations

    • Group Health Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    • ,
  • Jeannette M. Beasley

      Affiliations

    • Group Health Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    • Women's Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    • ,
  • Susan Reed

      Affiliations

    • Group Health Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    • Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    • ,
  • Susan M. Ott

      Affiliations

    • Department of Medicine, University of Washington, Seattle, WA 98195, USA

Received 23 May 2009 ,Revised 4 July 2009 ,Accepted 7 July 2009.

References 

  1. Chandra A, Martinez GM, Mosher WD, Abma JC, Jones J. Fertility, family planning, and reproductive health of U.S. women: data from the 2002 National Survey of Family Growth. Vital Health Stat. 2005;23:1–160
  2. Martins SL, Curtis KM, Glasier AF. Combined hormonal contraception and bone health: a systematic review. Contraception. 2006;73:445–469
  3. Hartard M, Kleinmond C, Wiseman M, Weissenbacher ER, Felsenberg D, Erben RG. Detrimental effect of oral contraceptives on parameters of bone mass and geometry in a cohort of 248 young women. Bone. 2007;40:444–450
  4. Polatti F, Perotti F, Filippa N, Gallina D, Nappi RE. Bone mass and long-term monophasic oral contraceptive treatment in young women. Contraception. 1995;51:221–224
  5. Register TC, Jayo MJ, Jerome CP. Oral contraceptive treatment inhibits the normal acquisition of bone mineral in skeletally immature young adult female monkeys. Osteoporos Int. 1997;7:348–353
  6. Recker RR, Davies KM, Hinders SM, Heaney RP, Stegman MR, Kimmel DB. Bone gain in young adult women. JAMA. 1992;268:2403–2408
  7. Nappi C, Di Spiezio Sardo A, Greco E, Tommaselli GA, Giordano E, Guida M. Effects of an oral contraceptive containing drospirenone on bone turnover and bone mineral density. Obstet Gynecol. 2005;105:53–60
  8. Reed SD, Scholes D, LaCroix AZ, Ichikawa L, Barlow WE, Ott SM. Longitudinal changes in bone density in relation to oral contraceptive use. Contraception. 2003;68:177–182
  9. Cromer BA, Bonny AE, Stager M, et al. Bone mineral density in adolescent females using injectable or oral contraceptives: a 24-month prospective study. Fertil Steril. 2008;90:2060–2067
  10. Petitti DB, Piaggio G, Mehta S, Cravioto MC, Meirik O. Steroid hormone contraception and bone mineral density: a cross-sectional study in an international population. The WHO Study of Hormonal Contraception and Bone Health. Obstet Gynecol. 2000;95:736–744
  11. Lloyd T, Taylor DS, Lin HM, Matthews AE, Eggli DF, Legro RS. Oral contraceptive use by teenage women does not affect peak bone mass: a longitudinal study. Fertil Steril. 2000;74:734–738
  12. Prior JC, Kirkland SA, Joseph L, et al. Oral contraceptive use and bone mineral density in premenopausal women: cross-sectional, population-based data from the Canadian Multicentre Osteoporosis Study. Can Med Assoc J. 2001;165:1023–1029
  13. Cromer BA, Stager M, Bonny A, et al. Depot medroxyprogesterone acetate, oral contraceptives and bone mineral density in a cohort of adolescent girls. J Adolesc Health. 2004;35:434–441
  14. Almstedt Shoepe H, Snow CM. Oral contraceptive use in young women is associated with lower bone mineral density than that of controls. Osteoporos Int. 2005;16:1538–1544
  15. Berenson AB, Rahman M, Breitkopf CR, Bi LX. Effects of depot medroxyprogesterone acetate and 20-microgram oral contraceptives on bone mineral density. Obstet Gynecol. 2008;112:788–799
  16. Pikkarainen E, Lehtonen-Veromaa M, Mottonen T, Kautiainen H, Viikari J. Estrogen-progestin contraceptive use during adolescence prevents bone mass acquisition: a 4-year follow-up study. Contraception. 2008;78:226–231
  17. Beksinska ME, Kleinschmidt I, Smit JA, Farley TM. Bone mineral density in a cohort of adolescents during use of norethisterone enanthate, depot-medroxyprogesterone acetate or combined oral contraceptives and after discontinuation of norethisterone enanthate. Contraception. 2009;79:345–349
  18. O'Brien SH, Kaizar EE, Gold MA, Kelleher KJ. Trends in prescribing patterns of hormonal contraceptives for adolescents. Contraception. 2008;77:264–269
  19. Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, Agurs-Collins T. Measurement characteristics of the Women's Health Initiative food frequency questionnaire. Ann Epidemiol. 1999;9:178–187
  20. Marcus AC. Memory aids in longitudinal health surveys: results from a field experiment. Am J Public Health. 1982;72:567–573
  21. Coulter A, Vessey M, McPherson K, Crossley B. The ability of women to recall their oral contraceptive histories. Contraception. 1986;33:127–137
  22. Cook LS, White JL, Stuart GC, Magliocco AM. The reliability of telephone interviews compared with in-person interviews using memory aids. Ann Epidemiol. 2003;13:495–501
  23. Ott SM, Ichikawa LE, LaCroix AZ, Scholes D. Navel jewelry artifacts and intravertebral variation in spine bone densitometry in adolescents and young women. J Clin Densitom. 2009;12:84–88
  24. Parsons TJ, Prentice A, Smith EA, Cole TJ, Compston JE. Bone mineral mass consolidation in young British adults. J Bone Miner Res. 1996;11:264–274
  25. Henry YM, Fatayerji D, Eastell R. Attainment of peak bone mass at the lumbar spine, femoral neck and radius in men and women: relative contributions of bone size and volumetric bone mineral density. Osteoporos Int. 2004;15:263–273
  26. Mah PM, Webster J, Jonsson P, Feldt-Rasmussen U, Koltowska-Haggstrom M, Ross RJ. Estrogen replacement in women of fertile years with hypopituitarism. J Clin Endocrinol Metab. 2005;90:5964–5969
  27. Mishell DRJ, Thorneycroft IH, Nakamura RM, Nagata Y, Stone SC. Serum estradiol in women ingesting combination oral contraceptive steroids. Am J Obstet Gynecol. 1972;114:923–928
  28. Spona J, Elstein M, Feichtinger W, et al. Shorter pill-free interval in combined oral contraceptives decreases follicular development. Contraception. 1996;54:71–77
  29. Perry RJ, Farquharson C, Ahmed SF. The role of sex steroids in controlling pubertal growth. Clin Endocrinol (Oxf). 2008;68:4–15
  30. Vanderschueren D, Venken K, Ophoff J, Bouillon R, Boonen S. Clinical review: sex steroids and the periosteum — reconsidering the roles of androgens and estrogens in periosteal expansion. J Clin Endocrinol Metab. 2006;91:378–382
  31. Walsh JS, Eastell R, Peel NF. Effects of depot medroxyprogesterone acetate on bone density and bone metabolism before and after peak bone mass: a case-control study. J Clin Endocrinol Metab. 2008;93:1317–1323
  32. van der Eerden BC, Karperien M, Wit JM. Systemic and local regulation of the growth plate. Endocr Rev. 2003;24:782–801
  33. Lopez LM, Grimes DA, Schulz KF, Curtis KM. Steroidal contraceptives: effect on bone fractures in women. Cochrane Database Syst Rev. 2009;CD006033
  34. Cooper C, Hannaford P, Croft P, Kay CR. Oral contraceptive pill use and fractures in women: a prospective study. Bone. 1993;14:41–45
  35. Vessey M, Mant J, Painter R. Oral contraception and other factors in relation to hospital referral for fracture. Findings in a large cohort study. Contraception. 1998;57:231–235
  36. Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk in very young women using combined oral contraceptives. Contraception. 2008;78:358–364
  37. Kanis JA, Oden A, Johnell O, et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007;18:1033–1046

☆ This study was funded by grant 1R01-HD31165-11 (Scholes) from the National Institute for Child Health and Human Development, National Institutes of Health. Dr. Beasley is a postdoctoral fellow supported by T-32 AG027677 from the National Institute on Aging.

PII: S0010-7824(09)00346-1

doi: 10.1016/j.contraception.2009.07.001

Contraception
Volume 81, Issue 1 , Pages 35-40 , January 2010

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