Contraception
Volume 81, Issue 1 , Pages 30-34 , January 2010

Prospective study of weight change in new adolescent users of DMPA, NET-EN, COCs, nonusers and discontinuers of hormonal contraception

  • Mags E. Beksinska

      Affiliations

    • Reproductive Health and HIV Research Unit, Department of Obstetrics and Gynaecology, University of the Witwatersrand, Mayville 4091, South Africa
    • Corresponding Author InformationCorresponding author. Tel.: +27 31 261 8840; fax: +27 31 261 8868.
    • ,
  • Jenni A. Smit

      Affiliations

    • Reproductive Health and HIV Research Unit, Department of Obstetrics and Gynaecology, University of the Witwatersrand, Mayville 4091, South Africa
    • ,
  • Immo Kleinschmidt

      Affiliations

    • London School of Hygiene and Tropical Medicine, WC1E London, UK
    • ,
  • Cecilia Milford

      Affiliations

    • Reproductive Health and HIV Research Unit, Department of Obstetrics and Gynaecology, University of the Witwatersrand, Mayville 4091, South Africa
    • ,
  • Timothy M.M. Farley

      Affiliations

    • UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, CH 1211 Geneva 27, Switzerland

Received 17 May 2009 ,Revised 23 June 2009 ,Accepted 20 July 2009.

References 

  1. World Health Organization Special Programme of Research Development and Research Training in Human Reproduction . Task Force on Long-acting Systemic Agents for the Regulation of Fertility Multinational comparative clinical evaluation of two long-acting injectable contraceptive steroids: norethisterone enanthate given in two dosage regimens and depot medroxyprogesterone acetate: final report. Contraception. 1983;23:1–20
  2. Harel Z, Biro FM, Kollar LM, Rauh JL. Adolescents reasons for and experience after discontinuation of the long-acting contraceptive Depo-Provera and Norplant. J Adolesc Health. 1996;19:118–123
  3. Gupta S. Weight gain on the combined pill — is it real?. Hum Reprod Update. 2000;6:427–431
  4. Howard G, Blair M, Fotherby K, Elder MG, Bye P. Seven years clinical experience of the injectable contraceptive, norethisterone oenanthate. Br J Fam Plann. 1985;11:9–16
  5. Bahamondes L, Del Castillo S, Tabares G, Arce XE, Perrotti M, Petta C. Comparison of weight increase in users of depot medroxyprogesterone acetate and copper IUD up to 5 years. Contraception. 2001;64:223–225
  6. Espey E, Steinhart J, Ogburn T, Qualls C. Depo-Provera associated with weight gain in Navajo women. Contraception. 2000;62:55–58
  7. Clark MK, Dillon JS, Sowers M, Nichols S. Weight, fat mass, and central distribution of fat increase when woman use depot-medroxyprogesterone acetate for contraception. Int J Obes. 2005;29:1252–1258
  8. Amatayakul K, Sivasomboon B, Thanangkul O. A study of the mechanism of weight gain in medroxyprogesterone acetate users. Contraception. 1980;22:605–622
  9. Risser WL, Gefter LR, Barratt MS, Risser JM. Weight change in adolescents who used hormonal contraception. J Adolesc Health. 1999;24:433–436
  10. Matson SC, Henderson KA, McGrath GJ. Physical findings and symptoms of depot medroxyprogesterone acetate use in adolescent females. J Pediatr Adolesc Gynecol. 1997;10:18–23
  11. Bonny A, Britto M, Huang B, Succop P, Slap GB. Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA). J Pediatr Adolesc Gynecol. 2004;17:109–115
  12. Bonny AE, Ziegler J, Harvey R, Debanne S, Cromer BA. Weight gain in obese and nonobese adolescent girls initiating depot medroxyprogesterone acetate, oral contraceptive pills, or no hormonal contraceptive method. Arch Pediatr Adolesc Med. 2006;160:40–45
  13. Mangan SA, Larsen PG, Hudson S. Overweight teens at increased risk for weight gain while using depot medroxyprogesterone acetate. J Pediatr Adolesc Gynecol. 2002;15:79–82
  14. Wellings K, Zhihong Z, Krentel A, Barrett G, Glasier A. Attitudes towards long-acting reversible methods of contraception in general practice in the UK. Contraception. 2007;76:208–214
  15. Gallo MF, Lopez LM, Grimes DA, Schulz KF, Helmerhorst FM. Combination contraceptives: effects on weight. Cochrane Database Syst Rev. 2008;8(4):CD003987
  16. Mainwaring R, Hales HA, Stevenson K, et al. Metabolic parameters, bleeding, and weight changes in US women using progestin-only contraceptives. Contraception. 1995;51:149–153
  17. Moore LL, Valuck R, McDougall C, Fink W. A comparative study of one-year weight gain among users of medroxyprogesterone acetate, levonorgestrel implants, and oral contraceptives. Contraception. 1995;52:215–219
  18. Taneepanichskul S, Reinprayoon D, Khaosaad P. Comparative study of weight change between long-term DMPA and IUD acceptors. Contraception. 1998;58:149–151
  19. Beksinska ME, Kleinschmidt I, Smit J, Farley TMM. Bone mineral density in adolescents using norethisterone enanthate, depot-medroxyprogesterone acetate, or combined oral contraceptives for contraception. Contraception. 2007;75:438–443
  20. Vaughan B, Trussell J, Kosy K, Singh S, Jones R. Discontinuation and resumption of contraceptive use: results from the 2002 National Survey of Family growth. Contraception. 2008;78:271–283

PII: S0010-7824(09)00352-7

doi: 10.1016/j.contraception.2009.07.007

Contraception
Volume 81, Issue 1 , Pages 30-34 , January 2010

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