Contraception
Volume 81, Issue 2 , Pages 102-106, February 2010

Effect of a continuous regimen of contraceptive combination of ethinylestradiol and drospirenone on lipid, carbohydrate and coagulation profiles

  • Rogério Bonassi Machado

      Affiliations

    • Department of Obstetrics and Gynecology, Jundiaí School of Medicine, 13202-550 Jundiaí, São Paulo, Brazil
    • Corresponding Author InformationCorresponding author. Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Jundiaí., R. Francisco Telles 250, 13202-550 Jundiaí, São Paulo, Brazil. Tel.: +55 11 4521 6466; fax: +55 11 4521 6040.
    • ,
  • Nilson Roberto de Melo

      Affiliations

    • Department of Obstetrics and Gynecology, School of Medicine, University of São Paulo, 05403-900 São Paulo, Brazil
    • ,
  • Hugo Maia Jr.

      Affiliations

    • Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH), 44015-340 Salvador, Bahia, Brazil
    • ,
  • Achilles Machado Cruz

      Affiliations

    • Department of Obstetrics and Gynecology, Jundiaí School of Medicine, 13202-550 Jundiaí, São Paulo, Brazil

Received 9 June 2009; accepted 25 August 2009. published online 05 October 2009.

Abstract 

Background

The objective of this study was to evaluate the effects of a contraceptive pill containing ethinylestradiol (30 mcg) and drospirenone (3 mg) in a continuous regimen on lipid, carbohydrate and coagulation parameters.

Study Design

This open, prospective, randomized study included 78 participants (mean age 27.8 years) who were randomized into two groups to use the pill continuously for 168 days or for six 28-day cycles with a 7-day hormone-free interval between cycles. Markers of lipid, carbohydrate and coagulation profiles were measured prior to initiation and after the 6 months of pill use.

Results

No statistically significant differences were found between the two contraceptive regimens with respect to carbohydrate or lipid profiles or in the parameters related to coagulation.

Conclusions

The contraceptive combination of ethinylestradiol and drospirenone used in a continuous regimen was associated with metabolic alterations similar to those found during the traditional cyclic regimen of oral contraceptive use.

Keywords: Oral contraceptive, Ethinylestradiol, Drospirenone, Continuous use, Metabolic profile, Blood coagulation

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PII: S0010-7824(09)00388-6

doi:10.1016/j.contraception.2009.08.009

Contraception
Volume 81, Issue 2 , Pages 102-106, February 2010

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