Contraception
Volume 81, Issue 1 , Pages 67-74 , January 2010

A randomized pilot study on the effectiveness and side-effect profiles of two doses of digoxin as fetocide when administered intraamniotically or intrafetally prior to second-trimester surgical abortion

  • Deborah Nucatola

      Affiliations

    • Planned Parenthood, Los Angeles, CA 90033, USA
    • Corresponding Author InformationCorresponding author. Planned Parenthood, Los Angeles, CA 90007, USA. Tel.: +1 213 284 3237; fax: +1 213 284 3352.
    • ,
  • Nitzan Roth

      Affiliations

    • Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    • ,
  • Mary Gatter

      Affiliations

    • Planned Parenthood, Los Angeles, CA 90033, USA

Received 20 October 2008 ,Revised 27 August 2009 ,Accepted 27 August 2009.

References 

  1. Jackson RA, Teplin VL, Drey EA, Thomas LJ, Darney P. Digoxin to facilitate late second-trimester abortion: a randomized, masked, placebo-controlled trial. Obstet Gynecol. 2001;97:471–476
  2. Molaei M, Jones HG, Weiselberg T, McManama M, Bassell J, Westhoff C. Effectiveness and safety of digoxin to induce fetal death prior to second-trimester abortion. Contraception. 2008;77:223–225
  3. Paul M, Lichtenberg ES, Borgatta L, Grimes DA, Stubblefield PG, Creinin MD. Management of unintended and abnormal pregnancy comprehensive abortion care. Oxford, UK: Wiley-Blackwell; 2009;
  4. Partial-Birth Abortion Ban Act of 2003, enrolled as agreed to or passed by both House and Senate from the US Government Printing Office, Washington, DC.
  5. Drey EA, Thomas LJ, Benowitz NL, Goldschlager N, Darney PD. Safety of intraamniotic digoxin administration before late second-trimester abortion by dilation and evacuation. Am J Obstet Gynecol. 2000;185:1063–1066
  6. Hern WM, Zen C, Ferguson K, Hart V, Haseman MV. Outpatient abortion for fetal anomaly and fetal death from 15–34 menstrual weeks' gestation: techniques and clinical management. Obstet Gynecol. 1993;81:301–306
  7. Hern W. Laminaria, induced fetal death and misoprostol in late abortion. Int J Gynaecol Obstet. 2001;75:279–286
  8. Taylor JS, Ellis GR. Racial differences in response to drug treatment: implications for pharmacotherapy of heart failure. Am J Cardiovasc Drugs. 2002;2:389–399
  9. Mathew J, Wittes J, McSherry F, et al. Digitalis Investigation Group Racial differences in outcome and treatment effect in congestive heart failure. Am Heart J. 2005;150:968–976

☆ The opinions expressed in this article do not necessarily reflect those of the Planned Parenthood Federation of America, Inc.

PII: S0010-7824(09)00409-0

doi: 10.1016/j.contraception.2009.08.014

Contraception
Volume 81, Issue 1 , Pages 67-74 , January 2010

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