Contraception
Volume 81, Issue 4 , Pages 269-274 , April 2010

Flexible mifepristone and misoprostol administration interval for first-trimester medical termination

  • Lilantha Wedisinghe

      Affiliations

    • Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, G4 0SF Glasgow, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 01412 114000; fax: +44 01412 115200.
    • ,
  • Deya Elsandabesee

      Affiliations

    • Department of Obstrtrics and Gynaecology, Princess Alexandra Hospital National Health Service Trust, CM20 1QX Harlow, UK

Received 8 February 2009 ,Revised 17 September 2009 ,Accepted 17 September 2009.

References 

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  2. El-Refaey H, Rajsekar D, Abdalla M, Calder L, Templeton A. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med. 1995;332:983–987
  3. Grimes DA. Medical abortion in early pregnancy: a review of the evidence. Obstet Gynaecol. 1997;89:790–796
  4. Guest J, Chein PFW, Thomson MAR, Kosseim ML. Randomized controlled trial comparing the efficacy of same-day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36 to 48 hour protocol. BJOG. 2007;1471:207–215
  5. Pymar HC, Creinin MD, Schwartz JL. Mifepristone followed on the same day by vaginal misoprostol for early abortion. Contraception. 2001;64:87–92
  6. Schreiber CA, Creinin MD, Harwood B, Murthy AS. A pilot study of mifepristone and misoprostol administered at the same time for abortion from 50 to 63 days. Contraception. 2005;71:447–450
  7. Murthy AS, Creinin MD, Harwood B, Schreiber C. A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation. Contraception. 2005;71:333–336
  8. Creinin MD, Schwartz JL, Pymar HC, Fink W. Efficacy of mifepristone followed on the same day by misoprostol for early termination of pregnancy: report of a randomized trial. BJOG. 2001;108:469–473
  9. Spitz IM, Bardin CW, Benton L, Robbins A. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med. 1998;338:1241–1247
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  11. Gemzell-Danielsson K, Bygdeman M, Aronsson A. Studies on the uterine contractility following mifepristone and various routes of misoprostol. Contraception. 2006;74:31–35
  12. Lähteenmäki P, Heikinheimo O, Croxatto H, et al. Pharmacokinetics and metabolism of RU 486. J Steroid Biochem. 1987;27:859–863
  13. Heikinheimo O, Kekkonen R, Lahteenmaki P. The pharmacokinetics of mifepristone in humans reveals insights into differential mechanisms of antiprogestin action. Contraception. 2003;68:421–426
  14. Tang OS, Ho PC. The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion. Contraception. 2006;74:26–30
  15. Heikinheimo O, Leminen R, Suhonen S. Termination of early pregnancy using flexible, low-dose mifepristone–misoprostol regimens. Contraception. 2007;76:456–460
  16. Schaff E. Evidence of shortening the time interval of prostaglandin after mifepristone for medical abortion. Contraception. 2006;74:42–44
  17. The National Health Service Evidence Health Information Resources. http://www.library.nhs.uk/Default.aspx (last viewed 3 January 2009).
  18. Creinin MD, Schreiber CA, Bednarek P, Lintu H, Wanger MS, Meyn LA. Mifepristone and misoprostol administered simultaneously versus 24 hours apart for abortion: a randomized controlled trial. Obstet Gynecol. 2007;109:885–894
  19. Creinin MD, Fox MC, Teal S, Chen A, Schaff EA, Meyn LA, et al. A randomized comparison of misoprostol 6 to 8 hours versus 24 hours after mifepristone for abortion. Obstet Gynecol. 2004;103:851–859
  20. Schaff EA, Fielding SL, Westhoff C, et al. Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: a randomized trial. JAMA. 2000;284:1948–1953
  21. Kapp N, Borgatta L, Ellis S, Stubblefield P. Simultaneous very low dose mifepristone and vaginal misoprostol for medical abortion. Contraception. 2006;73:525–527
  22. Li YT, Chen TH, Kuo TC. Efficacy of simultaneous use of mifepristone and misoprostol for early abortion. Intern J Gynecol Obstet. 2008;101:301
  23. Jain JK, Dutton C, Harwood B, et al. A prospective, double- blinded, placebo -controlled trial comparing mifepristone and vaginal misoprostol to vaginal misoprostol alone for elective termination of early pregnancy. Hum Reprod. 2002;17:1477–1482

☆ The corresponding (main) author self-funded the study.

PII: S0010-7824(09)00417-X

doi: 10.1016/j.contraception.2009.09.007

Contraception
Volume 81, Issue 4 , Pages 269-274 , April 2010

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