« Previous
Next »
Contraception
Volume 81, Issue 2
, Pages 165-171
, February 2010
Evaluation of the phosphodiesterase 3 inhibitor ORG 9935 as a contraceptive in female macaques: initial trials
References
- Fertility, family planning, and reproductive health of U.S. women: data from the 2002 National Survey of Family Growth. Vital and Health Statistics. 2005;1–160
- . Disparities in rates of unintended pregnancy in the United States, 1994 and 2001. Perspect Sex Reprod Health. 2006;38:90–96
- . Oral contraceptive risk assessment: a survey of 247 educated women. Obstet and Gyneco. 1993;82:112–117
- Role of cyclic nucleotide signaling in oocyte maturation. Mol Cell Endocrinol. 2002;187:153–159
- Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Develop Biol (Orlando). 1996;178:393–402
- Role of cyclic nucleotide phosphodiesterases in resumption of meiosis. Molec Cell Endocrinol. 1998;145:9–14
- . Effect of type 3 and type 4 phosphodiesterase inhibitors on the maintenance of bovine oocytes in meiotic arrest. Biol Reprod. 2002;66:180–184
- Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents. J Clin Invest. 1998;102:532–537
- Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro. Hum Reprod. 2002;17:2079–2084
- Human oocytes reversibly arrested in prophase I by phosphodiesterase type 3 inhibitor in vitro. Biol Reprod. 2003;69:1042–1052
- The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation during gonadotropin-stimulated ovarian cycles in rhesus macaques. Contraception. 2005;71:68–73
- The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques. Contraception. 2008;77:303–307
- In vitro fertilization–embryo transfer in nonhuman primates: the technique and its applications. Mol Reprod Dev. 1990;27:261–280
- . Dynamic expression of mRNAs and proteins for matrix metalloproteinases and their tissue inhibitors in the primate corpus luteum during the menstrual cycle. Mol Hum Reprod. 2002;8:833–840
- Chronic treatment of female rhesus monkeys with low doses of the antiprogestin ZK 137 316: establishment of a regimen that permits normal menstrual cyclicity. Hum Reprod. 1998;13:259–267
- Pregnancy detection by ultrasound and chorionic gonadotropin during the peri-implantation period in the macaque (Macaca fascicularis). Early Pregnancy. 1997;3:281–290
- A chronic, low-dose regimen of the antiprogestin ZK 137 316 prevents pregnancy in rhesus monkeys. Hum Reprod. 1998;13:2132–2138
- . Concentration-dependent mechanisms of ovulation inhibition by the progestin ST-1435. Fertil Steril. 1985;44:20–24
- . In: Improving access to quality care in family planning: medical eligibility criteria for contraceptive use. 3rd ed.. Geneva: WHO; 2003;p. 176
- Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition. Am J Physio. 1999;276:L412–L419
- Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells. J Cardiovas Pharmacol. 1999;34:497–504
- The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. Eur J Pharmacol. 1997;324:227–232
- . Importance of phosphodiesterase 3 for the lipolytic response in adipose tissue during insulin-induced hypoglycemia in normal man. Horm Metabo Rese. 1998;30:684–688
- . Inhibitors of cyclic nucleotide phosphodiesterase PDE3 as adjunct therapy for dilated cardiomyopathy. Expert Opin Investig Drugs. 2002;11:1529–1536
- . Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiolo Rev. 1995;75:725–748
- Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family). Cell Signalling. 1995;7:44555
- Recent progress in understanding the hormonal regulation of phosphodiesterases. Endoc Rev. 1995;16:370–389
☆ This research was supported by the Eunice Kennedy Shriver NICHD through R01-042710 and by U54 HD18185, U54 HD 031398 and NCRR RR00163.
PII: S0010-7824(09)00446-6
doi: 10.1016/j.contraception.2009.09.015
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Contraception
Volume 81, Issue 2
, Pages 165-171
, February 2010
