Contraception
Volume 81, Issue 2 , Pages 97-101 , February 2010

Mifepristone–misoprostol midtrimester abortion: impact of gestational age on the induction-to-abortion interval

  • Olga Gómez

      Affiliations

    • Department of Maternal–Fetal Medicine, ICGON, Hospital Clínic, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Department of Maternal–Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clínic, 08028 Barcelona, Spain. Tel.: +34 678451555; fax: +34 93 2275605.
    • ,
  • Aina Borrás

      Affiliations

    • Department of Maternal–Fetal Medicine, ICGON, Hospital Clínic, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain
    • ,
  • Aintzane Rabanal

      Affiliations

    • Department of Maternal–Fetal Medicine, ICGON, Hospital Clínic, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain
    • ,
  • Montse Palacio

      Affiliations

    • Department of Maternal–Fetal Medicine, ICGON, Hospital Clínic, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain
    • ,
  • Antonia Carceller

      Affiliations

    • Department of Pharmacy, ICGON, Hospital Clínic, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain
    • ,
  • Oriol Coll

      Affiliations

    • Department of Maternal–Fetal Medicine, ICGON, Hospital Clínic, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain
    • ,
  • Eduard Gratacós

      Affiliations

    • Department of Maternal–Fetal Medicine, ICGON, Hospital Clínic, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain

Received 8 September 2009 ,Revised 19 September 2009 ,Accepted 5 October 2009.

References 

  1. Medical methods for termination of pregnancy. WHO Technical Report Series 871. Geneva 1997.
  2. Gynaecology. RCoOa. The care of women requesting induced abortion. Evidence-based Clinical Guideline No. 7. The Royal College of Obstetricians and Gynaecology. September 2004.
  3. Gemzell-Danielsson K, Lalitkumar S. Second trimester medical abortion with mifepristone–misoprostol and misoprostol alone: a review of methods and management. Reprod Health Matters. 2008;16:162–172
  4. Lalitkumar S, Bygdeman M, Gemzell-Danielsson K. Mid-trimester induced abortion: a review. Hum Reprod Update. 2007;13:37–52
  5. Ho PC, Blumenthal BP, Gemzell-Danielsson K, Gómez Ponce de León R, Mittal S, Tang O. Misoprostol for the termination of pregnancy with a live fetus at 13 to 26 weeks. Intern J Gynaecol Obstet. 2007;99:S178–S181
  6. Ashok PW, Templeton A, Wagaarachchi PT, Flett GM. Midtrimester medical termination of pregnancy: a review of 1002 consecutive cases. Contraception. 2004;69:51–58
  7. Robinson HP, Fleming JE. A critical evaluation of sonar “crown–rump length” measurements. Br J Obstet Gynaecol. 1975;82:702–710
  8. Mul T, Mongelli M, Gardosi J. A comparative analysis of second-trimester ultrasound dating formulae in pregnancies conceived with artificial reproductive techniques. Ultrasound Obstet Gynecol. 1996;8:397–402
  9. Silva LV, Cecatti JG, Pinto e Silva JL, Amaral E, Barini R. Feticide does not modify duration of labor induction in cases of medical termination of pregnancy. Fetal Diagn Ther. 2008;23:192–197
  10. Ashok PW, Templeton A. Nonsurgical mid-trimester termination of pregnancy: a review of 500 consecutive cases. Br J Obstet Gynaecol. 1999;106:706–710
  11. Goh SE, Thong KJ. Induction of second trimester abortion (12–20 weeks) with mifepristone and misoprostol: a review of 386 consecutive cases. Contraception. 2006;73:516–519
  12. Kapp N, Borgatta L, Stubblefield P, Vragovic O, Moreno N. Mifepristone in second-trimester medical abortion: a randomized controlled trial. Obstet Gynecol. 2007;110:1304–1310
  13. Lo TK, Lau WL, Lai FK, et al. The effect of gestational age on the outcome of second-trimester termination of pregnancies for foetal abnormalities. Prenat Diagn. 2008;28:508–511
  14. Nilas L, Glavind-Kristensen M, Vejborg T, Knudsen UB. One or two day mifepristone–misoprostol interval for second trimester abortion. Acta Obstet Gynecol Scand. 2007;86:1117–1121
  15. Guix C, Palacio M, Figueras F, et al. Efficacy of two regimens of misoprostol for early second-trimester pregnancy termination. Fetal Diagn Ther. 2005;20:544–548
  16. Bagga R, Choudhary N, Suri V, et al. First and second trimester induced abortions in women with cardiac disorders: a 12-year analysis from a developing country. J Obstet Gynaecol. 2008;28:732–737

PII: S0010-7824(09)00447-8

doi: 10.1016/j.contraception.2009.10.001

Contraception
Volume 81, Issue 2 , Pages 97-101 , February 2010

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