Contraception
Volume 81, Issue 2 , Pages 161-164 , February 2010

Buccal misoprostol for cervical ripening prior to first trimester abortion

  • Hemang B. Panchal

      Affiliations

    • Department of Obstetrics and Gynecology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA
    • ,
  • Emily M. Godfrey

      Affiliations

    • Department of Obstetrics and Gynecology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA
    • Departments of Family Medicine and Community Health Sciences, University of Illinois-Chicago, Chicago, IL 60612, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 312 4133213.
    • ,
  • Ashlesha Patel

      Affiliations

    • Department of Obstetrics and Gynecology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA

Received 4 January 2009 ,Revised 23 September 2009 ,Accepted 6 October 2009.

References 

  1. Allen RH, Goldberg AB. Cervical dilation before first-trimester surgical abortion (<14 weeks' gestation). SFP Guideline 2007. Contraception. 2007;76:139–156
  2. Ngai SW, Chan YM, Tang OS, Ho PC. The use of misoprostol for pre-operative cervical dilatation prior to vacuum aspiration: a randomized trial. Hum Reprod. 1999;14:2139–2142
  3. Ramsey PS, Harris DY, Ogburn PL, Heise RH, Magtibay PM, Ramin KD. Comparative efficacy and cost of the prostaglandin analogs dinoprostone and misoprostol as labor preinduction agents. Am J Obstet Gynecol. 2003;188:560–565
  4. Fiala C, Gemzell-Danielsson K, Tang OS, von Hertzen H. Cervical priming with misoprostol prior to transcervical procedures. International Gynecol Obstet. 2007;99(Suppl 2):S168–S171
  5. MacIsaac L, Grossman D, Balistreri E, Darney P. A randomized controlled trial of laminaria, oral misoprostol, and vaginal misoprostol before abortion. Obstet Gynecol. 1999;93(5 Pt 1):766–770
  6. Aronsson A, Helstrom L, Gemzell-Danielsson K. Sublingual compared with oral misoprostol for cervical dilatation prior to vacuum aspiration: a randomized comparison. Contraception. 2004;69:165–169
  7. Saxena P, Salhan S, Sarda N. Comparison between the sublingual and oral route of misoprostol for pre-abortion cervical priming in first trimester abortions. Hum Reprod. 2004;19:77–80
  8. Tang OS, Schweer H, Seyberth HW, Lee SW, Ho PC. Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod. 2002;17:332–336
  9. Bergstrom S, Aronsson A. Misoprostol in resource poor countries. BMJ. 2008;336:1032
  10. Castleman LD, Oanh KT, Hyman AG, Thuy le T, Blumenthal PD. Introduction of the dilation and evacuation procedure for second-trimester abortion in Vietnam using manual vacuum aspiration and buccal misoprostol. Contraception. 2006;74:272–276
  11. Edelman AB, Buckmaster JG, Goetsch MF, Nichols MD, Jensen JT. Cervical preparation using laminaria with adjunctive buccal misoprostol before second-trimester dilation and evacuation procedures: a randomized clinical trial. Am J Obstet Gynecol. 2006;194:425–430
  12. Patel A, Talmont E, Morfesis J, et al. Adequacy and safety of buccal misoprostol for cervical preparation prior to termination of second-trimester pregnancy. Contraception. 2006;73:420–430
  13. Aronsson A, Bygdeman M, Gemzell-Danielsson K. Effects of misoprostol on uterine contractility following different routes of administration. Hum Reprod. 2004;19:81–84
  14. Meckstroth KR, Whitaker AK, Bertisch S, Goldberg AB, Darney PD. Misoprostol administered by epithelial routes: drug absorption and uterine response. Obstet Gynecol. 2006;108(3 Pt 1):582–590
  15. Schaff EA, DiCenzo R, Fielding SL. Comparison of misoprostol plasma concentrations following buccal and sublingual administration. Contraception. 2005;71:22–25
  16. Carbonell JL, Valazco A, Rodriquez Y, et al. Oral versus vaginal misoprostol for cervical priming in first-trimester abortion: a randomized trial. Eur J Contracept Reprod Health Care. 2001;6:134–140
  17. Singh K, Fong YF, Prasad RN, Dong F. Evacuation interval after vaginal misoprostol for preabortion cervical priming: a randomized trial. Obstet Gynecol. 1999;94:431–434
  18. Child TJ, Thomas J, Rees M, MacKenzie IZ. Morbidity of first trimester aspiration termination and the seniority of the surgeon. Hum Reprod. 2001;16:875–878
  19. Grimes DA, Schulz KF, Cates WJ. Prevention of uterine perforation during curettage abortion. JAMA. 1984;251:2108–2111
  20. Kaunitz AM, Rovira EZ, Grimes DA, Schulz KF. Abortions that fail. Obstet Gynecol. 1985;66:533–537
  21. Schulz KF, Grimes DA, Cates W. Measures to prevent cervical injury during suction curettage abortion. Lancet. 1983;1:1182–1185
  22. Okanlomo KA, Ngotho D, Moodley J. Effect of misoprostol for cervical ripening prior to pregnancy interruption before twelve weeks of gestation. East Afr Med J. 1999;76:552–555
  23. Saxena P, Salhan S, Sarda N. Role of sublingual misoprostol for cervical ripening prior to vacuum aspiration in first trimester interruption of pregnancy. Contraception. 2003;67:213–217
  24. Vimala N, Mittal S, Kumar S. Sublingual misoprostol for preabortion cervical ripening in first-trimester pregnancy termination. Contraception. 2003;67:295–297

☆ This research study was not funded. The authors report no conflict of interest.

PII: S0010-7824(09)00448-X

doi: 10.1016/j.contraception.2009.10.002

Contraception
Volume 81, Issue 2 , Pages 161-164 , February 2010

Article Tools