Clinical pharmacokinetics and interaction of centchroman — A mini review☆

Received 12 February 2009; received in revised form 12 November 2009; accepted 19 November 2009. published online 04 January 2010.

Abstract

This article provides a brief review of the information available regarding the published pharmacokinetics data for the nonsteroidal, once-a-week oral contraceptive, centchroman (INN: ormeloxifene). This agent is a unique need-oriented contraceptive agent which is included in the National Family Welfare Programme of India. Since 1991, centchroman has been used as a need-oriented contraceptive and is being given for treating dysfunctional bleeding of the uterus. Information regarding absorption, tissue distribution, elimination and kinetic interactions is discussed.

Keywords: Centchroman, Ormeloxifene, Selective estrogen receptor modulator, Pharmacokinetics, Drug–drug interaction

Pharmacokinetics and Metabolism Division, Central Drug Research Institute, CSIR, Lucknow 226001, India

Tel.: +91 522 2612411 18x4406; fax: +91 522 2623938/2623405.

☆ There was no funding provided for this study.

PII: S0010-7824(09)00516-2

doi:10.1016/j.contraception.2009.11.007

5 of 19