Two medical abortion regimens for late first-trimester termination of pregnancy: a prospective randomized trial☆
Received 14 August 2009; received in revised form 23 November 2009; accepted 3 December 2009. published online 15 January 2010.
Refers to erratum:
Erratum to “Two medical abortion regimens for late first-trimester termination of pregnancy: a prospective randomized trial” [Contraception 2010;81:323–7]
, 31 May 2010
Dalenda Chelly, Ines Najar, Fathia Boudaya, Malika Affes, Bechir Zouaoui, Ezzeddine Sfar, Hela Chelly, Mohamed Badis Channoufi
Contraception
August 2010 (Vol. 82, Issue 2, Page 217) Full Text |
Full-Text PDF (55 KB)
Abstract
Background
Medical abortion regimens based on the use of either misoprostol alone or in association with mifepristone have shown high efficacy and excellent safety profile in early pregnancy abortion. However, no clear recommendation is available for late first-trimester termination of pregnancy.
Study Design
A prospective randomized controlled trial included 122 women seeking medical abortion at 9 to 12 weeks of gestation. Seventy-three patients were given a fixed protocol of 200 mg of mifepristone followed 48 h later by 400 mcg oral misoprostol (Group 1). The second group of 49 patients was administered 800-mcg intravaginal single-dose misoprostol (Group 2). This study sought to compare safety, efficacy and acceptability of these two nonsurgical abortion regimens.
Results
Fifty-nine (80.8%) women in Group 1 had complete abortion vs. 38 (77.4%) women in Group 2 (p=.66). Abdominal pain was observed significantly more often in Group 2 (35/49 (71.4%) vs. 32/73 (43.8%) in Group 1, p<.0001. Medical abortion was equally acceptable among the two groups [37/49 (75.5%) and 55/73 (75.7%), p=.89].
Conclusion
For late first-trimester termination, a single 800-mcg vaginal dose of misoprostol seems to be as effective as the mifepristone+misoprostol regimen, with acceptable side effects.
ABSTRACT