Contraception
Volume 81, Issue 4 , Pages 323-327 , April 2010

Two medical abortion regimens for late first-trimester termination of pregnancy: a prospective randomized trial

Received 14 August 2009 ,Revised 23 November 2009 ,Accepted 3 December 2009.

References 

  1. Grimes DA, Creinin MD. Induced abortion: an overview for internists. Ann Intern Med. 2004;140:620–626
  2. Moreno Ruiz NL, Borgatta L, Yanow S, Kapp N, Wiebe ER, Winnikoff B. Alternatives to mifepristone for early medical abortion. Int J Gynaecol Obstet. 2007;96:212–218
  3. Hajri S, Blum J, Gueddana N, et al. Expanding medical abortion in Tunisia: women's experiences from a multi-site expansion study. Contraception. 2004;70:487–491
  4. Weeks A, Faundes A. Misoprostol in obstetrics and gynaecology. Int J Gynecol Obstet. 2007;99(Suppl 2):S156–S159
  5. Hamoda H, Ashok PW, Flett GM, Templeton A. Medical abortion at 64 to 91 days of gestation: a review of 483 consecutive cases. Am J Obstet Gynecol. 2003;188:1315–1319
  6. Von Hertzen H, Piaggio G, Marions L. Comparison of two doses and two routes of administration of misoprostol after pre-treatment with mifepristone for early pregnancy termination. Reprod Health. 2008;23:5
  7. Kulier R, Gulmezoglu AM, Hofmeyur GJ, Cheng LN, Campana A. Medical methods for first trimester abortion. Cochrane Database Syst Rev. 2004;2:CD002855
  8. Ashok PW, Kidd A, Flett GM, Fitzmaurice A, Graham W, Templeton A. A randomized comparison of medical abortion and surgical vacuum aspiration at 10–13 weeks gestation. Hum Reprod. 2002;17:92–98
  9. Hamoda H, Ashok PW, Flett GM, Templeton A. Medical abortion at 9–13 weeks' gestation: a review of 1076 consecutive cases. Contraception. 2005;71:327–332
  10. Carbonell Esteve JL, Varela L, Velazco A, Cabezas E, Tanda R, Sánchez C. Vaginal misoprostol for late first trimester abortion. Contraception. 1998;57:329–333
  11. Ashok PW, Flett GM, Templeton A. Termination of pregnancy at 9–13 weeks' amenorrhoea with mifepristone and misoprostol. Lancet. 1998;352:542–543
  12. Carbonell JL, Varela L, Velazco A, Fernandez C. The use of misoprostol for termination of early pregnancy. Contraception. 1997;55:165–168
  13. Bracken H, Ngoc NT, Schaff E, et al. Mifepristone followed in 24 hours to 48 hours by misoprostol for late first-trimester abortion. Obstet Gynecol. 2007;109:895–901
  14. Von Hertzen H, Piaggio G, Huong NT, et al. Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled, equivalence trial. Lancet. 2007;369:1938–1946
  15. Gemzell-Danielsson K, Lalitkumar S. Second trimester medical abortion with mifepristone–misoprostol and misoprostol alone: a review of methods and management. Reprod Health Matters. 2008;16(Suppl 31):162–172
  16. Wiebe ER. Choosing between surgical abortion and medical abortion induced with methotrexate and misoprostol. Contraception. 1997;55:67–71
  17. Zikopoulos KA, Papanikolaou EG, Kalantaridou SN, et al. Early pregnancy termination with vaginal misoprostol before and after 42 days gestation. Hum Reprod. 2002;17:3079–3083
  18. Ashok PW, Templeton A. Nonsurgical mid-trimester termination of pregnancy: a review of 500 consecutive cases. Br J Obstet Gynaecol. 1999;106:706–710
  19. Grimes DA, Schulz KF, Cates W, Tyler CW. Local versus general anesthesia: which is safer for performing suction curettage abortions?. Am J Obstet Gynecol. 1979;135:1030–1035
  20. Schulz KF, Grimes DA, Cates W. Measures to prevent cervical injury during suction curettage abortion. Lancet. 1983;1:1182–1185
  21. Cameron S, Glasier A, Logan J, Benton L, Baird D. Impact of the introduction of a new medical method on therapeutic abortions at the Royal Infirmary of Edinburgh. Br J Obstet Gynaecol. 1996;103:1222–1229
  22. Fjerstad M, Trussell J, Sivin I, Lichtenberg ES, Cullins V. Rates of serious infection after changes in regimens for medical abortion. N Engl J Med. 2009;361:145–151
  23. Thonneau P, Poirel H, Fougeyrollas B, et al. A comparative analysis of fall in haemoglobin following abortions conducted by mifepristone (600 mg) and vacuum aspiration. Hum Reprod. 1995;10:1512–1515
  24. Henshaw RC, Naji SA, Russel IT, Templeton AA. comparison of medical abortion (using mifepristone and gemeprost) with surgical vacuum aspiration. Efficacy and early medical sequelae. Hum Reprod. 1994;9:2167–2172

☆ The study was funded by the National Board of Family and Population.

PII: S0010-7824(09)00520-4

doi: 10.1016/j.contraception.2009.12.002

Contraception
Volume 81, Issue 4 , Pages 323-327 , April 2010

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