Contraception
Volume 81, Issue 5 , Pages 414-420 , May 2010

Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation

Received 9 November 2009 ,Revised 10 December 2009 ,Accepted 16 December 2009.

References 

  1. Croxatto HB, Ortiz ME, Müller AL. Mechanisms of action of emergency contraception. Steroids. 2003;68:1095–1098
  2. Hapangama D, Glasier AF, Baird DT. The effects of peri-ovulatory administration of levonorgestrel on the menstrual cycle. Contraception. 2001;63:123–129
  3. Durand M, Cravioto MC, Raymond EG, et al. On the mechanism of action of short-term levonorgestrel administration in emergency contraception. Contraception. 2001;64:227–234
  4. Marions L, Hultenby K, Lindell I, Sun X, Stabi B, Gemzell-Danielsson K. Emergency contraception with mifepristone and levonorgestrel: mechanism of action. Obstet Gynecol. 2002;100:65–71
  5. Marions L, Cekan SZ, Bygdeman M, Gemzell-Danielsson K. Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function. Contraception. 2004;69:373–377
  6. Croxatto HB, Brache V, Pavez M, et al. Pituitary-ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75 mg dose given on the days preceding ovulation. Contraception. 2004;70:442–450
  7. Kesserü E, Garmendia F, Westphal M, Parada J. The hormonal and peripheral effects of d-norgestrel in postcoital contraception. Contraception. 1974;10:411–424
  8. Brache V, Faúndes A, Johansson E, Alvarez F. Anovulation, inadequate luteal phase and poor sperm penetration in cervical mucus during prolonged use of Norplant® implants. Contraception. 1985;31:261–273
  9. Croxatto HB, Diaz S, Salvatierra AM, Morales P, Ebensperger C, Brandeis A. Treatment with Norplant® subdermal implants inhibits sperm penetration through cervical mucus in vitro. Contraception. 1987;36:193–201
  10. Yeung WS, Chiu PC, Wang CH, Yao YQ, Ho PC. The effects of levonorgestrel on various sperm functions. Contraception. 2002;66:453–457
  11. Bahamondes L, Nascimento JAA, Munuce MJ, Fazano F, Faúndes A. The in vitro effect of levonorgestrel on the acrosome reaction of human spermatozoa from fertile men. Contraception. 2003;68:55–59
  12. Palomino A, Boric A, Gabler F, Espinoza A, Vega M, Devoto L. Efecto de levonorgestrel como anticonceptivo de emergencia sobre receptores de progesterona durante la ventana de implantación. Revista Cubana de Salud Pública. 2003;29(Suppl № 1):38
  13. Gemzell-Danielsson K, Marions L. Mechanism of action of mifepristone and levonorgestrel when used for emergency contraception. Hum Reprod Update. 2004;10:341–348
  14. Ugocsai G, Rozsa M, Ugocsai P. Scanning electron microscopic (SEM) changes of the endometrium in women taking high doses of levonorgestrel as emergency postcoital contraception. Contraception. 2002;66:433–437
  15. Lalitkumar PG, Lalitkumar S, Meng CX, et al. Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model. Hum Reprod. 2007;22:3031–3037
  16. Müller AL, Llados CM, Croxatto HB. Post-coital treatment with levonorgestrel does not disrupt post-fertilization events in the rat. Contraception. 2003;67:415–419
  17. Ortiz ME, Ortiz RE, Fuentes M, Parraguez VH, Croxatto HB. Post-coital administration of levonorgestrel does not interfere with post-fertilization events in the new-world monkey Cebus apella. Hum Reprod. 2004;19:1352–1356
  18. Novikova N, Weisberg E, Stanczyk FZ, Croxatto HB, Fraser IS. Effectiveness of levonorgestrel emergency contraception given before or after ovulation — a pilot study. Contraception. 2007;75:112–118
  19. Heiken JP, Lee JKT. MR imaging of the pelvis. Radiology. 1988;166:11–16
  20. Zawin M. Imaging of the normal female pelvis. In:  Schwartz LB editors. Diagnostic imaging for reproductive failure. New York: The Parthenon Publishing Group Inc.; 1998;p. 37–48
  21. WHO . Laboratory manual for the examination of human semen and sperm–cervical mucus interaction. In: WHO Special Programme of Research, Development and Research Training in Human Reproduction  editors. Sperm–cervical mucus interaction. 4th ed.. Cambridge: University Press; 1999;p. 51–58
  22. Wilcox AJ, Weinberg CR, Baird DD. Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy and sex of the baby. N Engl J Med. 1995;333:1517–1521
  23. Ho PC, Kwan MS. A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception. Hum Reprod. 1993;8:389–392
  24. Task Force on Postovulatory Methods of Fertility Regulation . Randomized controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Lancet. 1998;352:428–433
  25. von Hertzen H, Piaggio G, Din J, et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet. 2002;360:1803–1810
  26. Arowojolu AO, Okewole IA, Adekunle AO. Comparative evaluation of the effectiveness and safety of two regimens of levonorgestrel for emergency contraception in Nigerians. Contraception. 2002;66:269–273
  27. von Hertzen H, Piaggio G. Levonorgestrel and mifepristone in emergency contraception. Steroids. 2003;68:1107–1113
  28. Hamoda H, Ashok PW, Stalder C, Flett GM, Kennedy E, Templeton A. A randomized trial of mifepristone (10 mg) and levonorgestrel for emergency contraception. Obstet Gynecol. 2004;104:1307–1313
  29. Espinós JJ, Rodriguez-Espinosa J, Senosiain R, et al. The role of matching menstrual data with hormonal measurements in evaluating effectiveness of postcoital contraception. Contraception. 1999;60:243–247
  30. Stirling A, Glasier A. Estimating the efficacy of emergency contraception — how reliable is the data?. Contraception. 2002;66:19–22
  31. Severi FM, Bocchi C, Florio P, Cobellis L, Ignacchiti E, Petraglia F. Transvaginal ultrasonography in women receiving emergency contraception. Fertil Steril. 2003;79:1074–1077

 This study has been supported by grants 1060252 and FB0807 from Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) and by grant A 65559 from the World Health Organization, Department of Reproductive Health and Research (WHO/RHR).

PII: S0010-7824(09)00541-1

doi: 10.1016/j.contraception.2009.12.015

Contraception
Volume 81, Issue 5 , Pages 414-420 , May 2010