Contraception
Volume 81, Issue 5 , Pages 441-445 , May 2010

Randomized trial of buccal versus vaginal misoprostol for induction of second trimester abortion

Received 9 July 2009 ,Revised 18 December 2009 ,Accepted 22 December 2009.

References 

  1. Kapp N, von Hertzen H. Medical methods to induce abortion in the second trimester. In:  Paul M,  Lichtenberg ES,  Borgatta L,  Grimes D,  Stubblefield P,  Creinin M editor. A clinician's guide to medical and surgical abortion. United Kingdom: Blackwell Publishing Ltd; 2009;p. 178–192
  2. Dickinson JE, Evans SF. The optimization of intravaginal misoprostol dosing schedules in second-trimester pregnancy termination. Am J Obstet and Gynecol. 2002;1186:470–474
  3. Ramin KD. High-dose oral misoprostol for mid-trimester pregnancy interruption. Gynecol Obstet Invest. 2002;54:176–179
  4. Ngai SW, Tang OS, HO PC. Randomization comparison of vaginal (200 microg every 3 h) and oral (400 microg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy. Hum Reprod. 2000;15:2205–2208
  5. Zieman M, Fong SK, Benowitz NL, et al. Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol. 1997;90:88–92
  6. Danielsson KG, Marions L, Rodriguez A, et al. Comparison between oral and vaginal administration of misoprostol on uterine contractility. Obstet Gynecol. 1999;93:275–279
  7. Gilbert A. A randomized trial of oral versus vaginal administration of misoprostol for the purpose of mid-trimester termination of pregnancy. Aust NZ J Obstet Gynecol. 2001;41:407–410
  8. Bebbington MW, Kent N, Lim K, et al. A randomized controlled trial comparing two protocols for the use of misoprostol inmidtrimester pregnancy termination. Am J Obstet Gynecol. 2002;187:853–857
  9. Fisher SA, Mackenzie VP, Davies GA. Oral versus vaginal misoprostol for induction of labor: a double-blind randomized controlled trial. Am J Obstet Gynecol. 2001;185:906–910
  10. Middleton T, Schaff E, Fielding SL, et al. Randomized trial of mifepristone and buccal or vaginal misoprostol for abortion through 56 days of last menstrual period. Contraception. 2005;72:328–332
  11. Todd CS. Buccal misoprostol as cervical preparation for second trimester pregnancy termination. Contraception. 2002;65:415–418
  12. Carlan SJ. Buccal versus intravaginal misoprostol administration for cervical ripening. Am J Obstet Gynecol. 2002;186:229–233
  13. Patel A, Talmont E, Morfesis J, et al. Planned parenthood federation of America buccal misoprostol waiver group. Adequacy and safety of buccal misoprostol for cervical preparation prior to termination of second-trimester pregnancy. Contraception. 2006;73:420–430
  14. Jackson RA, Teplin VL, Drey EA, et al. Digoxin to facilitate late second trimester abortion: a randomized, masked, placebo-controlled trial. Obstet Gynecol. 2001;97:471–476
  15. Feldman DM, Borgida AF, Rodis JF, et al. A randomized comparison of two regimens of misoprostol for second-trimester pregnancy termination. Am J Obstet Gynecol. 2003;189:710–713
  16. El-Refaey H, Templeton A. Pregnancy: induction of abortion in the second trimester combination of misoprostol and mifepristone: a randomized comparison between two misoprostol regimens. Hum Reprod. 1995;10:475–478
  17. Dickinson JE, Evans SF. A comparison of oral misoprostol with vaginal misoprostol administration in second-trimester pregnancy termination for fetal anomaly. Obstet Gynecol. 2003;101:1294–1299

PII: S0010-7824(09)00556-3

doi: 10.1016/j.contraception.2009.12.018

Contraception
Volume 81, Issue 5 , Pages 441-445 , May 2010