Contraception
Volume 81, Issue 6 , Pages 496-500 , June 2010

A nonhormonal model for emergency contraception: prostaglandin synthesis inhibitor effects on luteal function and lifespan, a pilot study

  • Alison B. Edelman

      Affiliations

    • Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, 97239, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 503 494 5949; fax: +1 503 494 3111.
    • ,
  • Jeffrey T. Jensen

      Affiliations

    • Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, 97239, USA
    • ,
  • Jon D. Hennebold

      Affiliations

    • Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, 97239, USA
    • Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon, 97006, USA

Received 17 November 2009 ,Revised 29 December 2009 ,Accepted 6 January 2010.

References 

  1. Kost K, Singh S, Vaughan B, Trussell J, Bankole A. Estimates of contraceptive failure from the 2002 National Survey of Family Growth. Contraception. 2008;77:10–21
  2. WHO Contraceptive medical eligibility criteria. www.who.int2009;Accessed June 16, 2009
  3. Croxatto H, Devoto L, Durand M, et al. Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature. Contraception. 2001;63:111–121
  4. Hodgen GD, Itskovitz J. Recognition and maintenance of pregnancy. In:  Knobil E,  Neill JD editor. The physiology of reproduction. New York: Raven; 1988;p. 1995–2021
  5. Baird DD, Weinberg CR, McConnaughey DR, Wilcox AJ. Rescue of the corpus luteum in human pregnancy. Biol Reprod. 2003;68:448–456
  6. Stouffer RL. Structure, function, and regulation of the corpus luteum. In:  Knobil E,  Neill JD editor. The Physiology of Reproduction. New York: Raven; 1988;p. 475–526
  7. Stouffer RL, Nixon WE, Hodgen GD. Disparate effects of prostaglandins on basal and gonadotropin-stimulated progesterone production by luteal cells isolated from rhesus monkeys during the menstrual cycle and pregnancy. Biol Reprod. 1979;20:897–903
  8. Dennefors BL, Sjogren A, Hamberger L. Progesterone and adenosine 3′,5′-monophosphate formation by isolated human corpora lutea of different ages: influences of human chorionic gonadotropin and prostaglandins. J Clin Endocrinol Metab. 1982;55:102–107
  9. Zelinski-Wooten MB, Stouffer RL. Intraluteal infusions of prostaglandins of the E, D, I, and A series prevent PGF2 alpha-induced, but not spontaneous, luteal regression in rhesus monkeys. Biol Reprod. 1990;43:507–516
  10. Hahlin M, Dennefors B, Johanson C, Hamberger L. Luteotropic effects of prostaglandin E2 on the human corpus luteum of the menstrual cycle and early pregnancy. J Clin Endocrinol Metab. 1988;66:909–914
  11. Sargent EL, Baughman WL, Novy MJ, Stouffer RL. Intraluteal infusion of a prostaglandin synthesis inhibitor, sodium meclofenamate, causes premature luteolysis in rhesus monkeys. Endocrinology. 1988;123:2261–2269
  12. Yan M, Myung S, Fink S, et al. 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. PNAS. 2009;106:9409–9413
  13. Massai MR, Forcelledo ML, Brache V, et al. Does meloxicam increase the incidence of anovulation induced by single administration of levonorgestrel in emergency contraception. A pilot study. Hum Reprod. 2007;22:434–439
  14. Pall M, Fridén BE, Brännström M. Induction of delayed follicular rupture in the human by the selective COX-2 inhibitor rofecoxib: a randomized double-blind study. Hum Reprod. 2001;16:1323–1328
  15. Salhab AS, Gharaibeh MN, Shomaf MS, Amro BI. Meloxicam inhibits rabbit ovulation. Contraception. 2001;63:329–333
  16. Salhab AS, Amro BI, Shomaf MS. Further investigation on meloxicam contraceptivity in female rabbits: luteinizing unruptured follicles, a microscopic evidence. Contraception. 2003;67:485–489
  17. Smith G, Roberts R, Hall C. Reversible ovulatory failure associated with the development of luteinized unruptured follicles in women with inflammatory arthritis taking non-steroidal anti-inflammatory drugs. Br J Rheumatol. 1996;35:458–462
  18. Killick S, Elstein M. Pharmacologic production of luteinized unruptured follicles by prostaglandins synthetase inhibitors. Fertil Steril. 1987;47:773–777
  19. Mizuyachi K, Son DS, Rozman KK, Terranova PF. Alteration in ovarian gene expression in response to 2,3,7,8,-tetrachlorodibenzo-p-dioxin: reduction of cyclooxygenase-2 in the blockage of ovulation. Reprod Toxicol. 2002;16:299–307
  20. Bogan RL, Murphy MJ, Stouffer RL, Hennebold JD. Prostaglandin synthesis, metabolism, and signaling potential in the rhesus macaque corpus luteum throughout the luteal phase of the menstrual cycle. Endocrinology. 2008;149:5861–5871

☆ This study was supported by Society for Family Planning.

PII: S0010-7824(10)00005-3

doi: 10.1016/j.contraception.2010.01.004

Contraception
Volume 81, Issue 6 , Pages 496-500 , June 2010

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