Contraception
Volume 81, Issue 6 , Pages 481-486 , June 2010

Double-blind, randomized, placebo-controlled study on the effect of misoprostol on ease of consecutive insertion of the levonorgestrel-releasing intrauterine system

  • Oskari Heikinheimo

      Affiliations

    • Department of Obstetrics and Gynecology, Helsinki University Central Hospital, 00029-HUS Helsinki, Finland
    • ,
  • Pirjo Inki

      Affiliations

    • Bayer Schering Pharma AG, DE-13342 Berlin, Germany
    • ,
  • Michael Kunz

      Affiliations

    • Bayer Schering Pharma AG, DE-13342 Berlin, Germany
    • ,
  • Sule Parmhed

      Affiliations

    • Sesam-Södersjukhuset, SE-11883 Stockholm, Sweden
    • ,
  • Anna-Maija Anttila

      Affiliations

    • Suomen Terveystalo, FI-33100 Tampere, Finland
    • ,
  • Sven-Eric Olsson

      Affiliations

    • Prima Liv KK, DS AB Danderyds sjukhus AB, SE-18288 Stockholm, Sweden
    • ,
  • Ritva Hurskainen

      Affiliations

    • Hyvinkää Hospital, FI-05800 Hyvinkää, Finland
    • ,
  • Kristina Gemzell-Danielsson

      Affiliations

    • Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institutet/University Hospital SE-17176 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 8 51772128; fax: +46 851774314.

Received 7 July 2009 ,Revised 16 November 2009 ,Accepted 26 January 2010.

References 

  1. Rönnerdag M, Odlind V. Health effects of long-term use of the intrauterine levonorgestrel-releasing system. A follow-up study over 12 years of continuous use. Acta Obstet Gynecol Scand. 1999;78:716–721
  2. Fiala C, Gemzell-Danielsson K, Tang OS, von Hertzen H. Cervical priming with misoprostol prior to transcervical procedures. Int J Gynaecol Obstet. 2007;99(Suppl 2):S168–S171
  3. Ho PC, Ngai SW, Liu KL, Wong GC, Lee SW. Vaginal misoprostol compared with oral misoprostol in termination of second trimester pregnancy. Obstet Gynecol. 1997;90:735–738
  4. Ngai SW, Chan YM, Liu KL, Ho PC. Oral misoprostol for cervical priming in non-pregnant women. Hum Reprod. 1997;12:2373–2375
  5. Ngai SW, Chan YM, Tang OS, Ho PC. The use of misoprostol for pre-operative cervical dilatation prior to vacuum aspiration: a randomized trial. Hum Reprod. 1999;14:2139–2142
  6. Thomas JA, Leyland N, Durand N, Windrim RC. The use of oral misoprostol as a cervical ripening agent in operative hysteroscopy: a double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2002;186:876–879
  7. Sääv I, Aronsson A, Marions L, Stephansson O, Gemzell-Danielsson K. Cervical priming with sublingual misoprostol prior to insertion of an intrauterine device in nulliparous women: a randomized controlled trial. Hum Reprod. 2007;22:2647–2652
  8. Li YT, Kuo TC, Kuan LC, Chu YC. Cervical softening with vaginal misoprostol before intrauterine device insertion. Int J Gynaecol Obstet. 2005;89:67–68
  9. El-Refaey H, Rajasekar D, Abdalla M, Calder L, Templeton A. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med. 1995;332:983–987
  10. Aronsson A, Helstrom L, Gemzell-Danielsson K. Sublingual compared with oral misoprostol for cervical dilatation prior to vacuum aspiration: a randomized comparison. Contraception. 2004;69:165–169
  11. Zieman M, Fong SK, Benowitz NL, Banskter D, Darney PD. Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol. 1997;90:88–92
  12. Gemzell-Danielsson K, Marions L, Rodriguez A, Spur BW, Wong PY, Bygdeman M. Comparison between oral and vaginal administration of misoprostol on uterine contractility. Obstet Gynecol. 1999;93:275–280
  13. Tang OS, Schweer H, Seyberth HW, Lee SW, Ho PC. Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod. 2002;17:332–336
  14. Aronsson A, Fiala C, Stephansson O, Granath F, Watzer B, Schweer H, et al. Pharmacokinetic profiles up to 12 h after administration of vaginal, sublingual and slow-release oral misoprostol. Hum Reprod. 2007;22:1912–1918
  15. Bisharah M, Al-Fozan H, Tulandi T. A randomized trial of sublingual misoprostol for cervical priming before hysteroscopy. J Am Assoc Gynecol Laparosc. 2003;10:390–391
  16. Gemzell-Danielsson K, Inki P, Boubli L, O'Flynn M, Kunz M, Heikinheimo O. Bleeding pattern and safety of consecutive use of the levonorgestrel-releasing intrauterine system (LNG-IUS) — a multicentre prospective study. Hum Reprod. 2010;25:354–359
  17. Jensen JT, Nelson AL, Costales AC. Subject and clinician experience with the levonorgestrel-releasing intrauterine system. Contraception. 2008;1:22–29
  18. Hamoda H, Ashok PW, Flett GM, Templeton A. A randomized controlled comparison of sublingual and vaginal administration of misoprostol for cervical priming before first-trimester surgical abortion. Am J Obstet Gynecol. 2004;190:55–59

PII: S0010-7824(10)00040-5

doi: 10.1016/j.contraception.2010.01.020

Contraception
Volume 81, Issue 6 , Pages 481-486 , June 2010

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