Contraception
Volume 82, Issue 3 , Pages 276-280 , September 2010

Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome

  • Vincenzo De Leo

      Affiliations

    • Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, 53100 Siena, Italy
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynecology, Policlinico Le Scotte, 53100 Siena, Italy. Tel.: +39 0577 233465; fax: +39 0577 233464.
    • ,
  • Alessandra Di Sabatino

      Affiliations

    • Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, 53100 Siena, Italy
    • ,
  • Maria C. Musacchio

      Affiliations

    • Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, 53100 Siena, Italy
    • ,
  • Giuseppe Morgante

      Affiliations

    • Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, 53100 Siena, Italy
    • ,
  • Valeria Scolaro

      Affiliations

    • Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, 53100 Siena, Italy
    • ,
  • Antonio Cianci

      Affiliations

    • Section of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Catania, Catania, Italy
    • ,
  • Felice Petraglia

      Affiliations

    • Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, 53100 Siena, Italy

Received 5 November 2009 ,Revised 29 March 2010 ,Accepted 2 April 2010.

References 

  1. De Leo V, La Marca A, Petraglia F. Insulin-lowering agents in the management of polycystic ovary syndrome. Endocr Rev. 2003;24:633–667
  2. Raudrant D, Rabe T. Progestogens with antiandrogenic properties. Drugs. 2003;63:463–492
  3. Wiegratz I, Jung-Hoffmann C, Kuhl H. Effect of two oral contraceptives containing ethinylestradiol and gestodene or norgestimate upon androgen parameters and serum binding proteins. Contraception. 1995;51:341–346
  4. De Leo V, Morgante G, Piomboni P, et al. Evaluation of effects of an oral contraceptive containing ethinylestradiol combined with drospirenone on adrenal steroidogenesis in hyperandrogenic women with polycystic ovary syndrome. Fertil Steril. 2007;88(1):113–117
  5. Van der Spuy ZM, le Roux PA. Cyproterone acetate for hirsutism. Cochrane Database Syst Rev. 2003;CD001125
  6. Guido M, Romualdi D, Giuliani M, et al. Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study. J Clin Endocrinol Metab. 2004;89:2817–2823
  7. Palep-Singh M, Mook K, Barth J, et al. An observational study of Yasmin in the management of women with polycystic ovary syndrome. J Fam Plann Reprod Health Care. 2004;30:163–165
  8. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41–47
  9. Wiegratz I, Kutschera E, Lee JH, et al. Effect of four different oral contraceptives on various sex hormones and serum-binding globulins. Contraception. 2003;67:25–32
  10. Blume-Peytavi U, Hahn S. Medical treatment of hirsutism. Dermatol Ther. 2008;329–339
  11. Vrbíková J, Cibula D. Combined oral contraceptives in the treatment of polycystic ovary syndrome. Hum Reprod Update. 2005;11:277–291
  12. Van der Vange N, Blankenstein MA, Kloosterboer HJ, et al. Effects of seven low-dose combined oral contraceptives on sex hormone binding globulin, corticosteroid binding globulin, total and free testosterone. Contraception. 1990;41:345–352
  13. Falsetti L, Gambera A, Platto C, et al. Management of hirsutism. Am J Clin Dermatol. 2000;1:89–99
  14. Falsetti L, Gambera A, Tisi GC. Efficacy of the combination ethinyl oestradiol and cyproterone acetate on the endocrine, clinical and ultrasonographic profile in polycystic ovarian syndrome. Hum Reprod. 2001;16:36–42
  15. Falsetti L. Sex hormone-binding globulin during treatment with various combined oral contraceptives. Gynecol Obstet. 1988;2:131–136
  16. Falsetti L, Galbigliani E, Comberti E, et al. Effetti di 8 contraccettivi orali su SHBG, CBG, e testosterone libero. Perspectives Gynecol Obstet. 1989;6:65–70

PII: S0010-7824(10)00139-3

doi: 10.1016/j.contraception.2010.04.002

Contraception
Volume 82, Issue 3 , Pages 276-280 , September 2010

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