Contraception
Volume 82, Issue 6 , Pages 497-502 , December 2010

Safety and bleeding profile of continuous levonorgestrel 90 mcg/ethinyl estradiol 20 mcg based on 2 years of clinical trial data in Canada

  • Robert L. Reid

      Affiliations

    • Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada K7L 4V7
    • Corresponding Author InformationCorresponding author. Division of REI, Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada K7L 4V7. Tel.: +1 613 542 9473; fax: +1 613 533 6779.
    • ,
  • Michel P. Fortier

      Affiliations

    • Clinique de Recherche en Santé des femmes, Québec, Québec, Canada G1S 2L6
    • ,
  • Lynne Smith

      Affiliations

    • Pfizer, Inc., Collegeville, PA 19101, USA
    • ,
  • Sebastian Mirkin

      Affiliations

    • Pfizer, Inc., Collegeville, PA 19101, USA
    • ,
  • Gary S. Grubb

      Affiliations

    • Wyeth Research (formerly), Collegeville, PA 19101, USA
    • ,
  • Ginger D. Constantine

      Affiliations

    • Wyeth Research (formerly), Collegeville, PA 19101, USA

Received 22 October 2009 ,Revised 1 June 2010 ,Accepted 2 June 2010.

References 

  1. Kwiecien M, Edelman A, Nichols MD, Jensen JT. Bleeding patterns and patient acceptability of standard or continuous dosing regimens of a low-dose oral contraceptive: a randomized trial. Contraception. 2003;67:9–13
  2. Sulak PJ, Cressman BE, Waldrop E, Holleman S, Kuehl TJ. Extending the duration of active oral contraceptive pills to manage hormone withdrawal symptoms. Obstet Gynecol. 1997;89:179–183
  3. Guilbert E, Boroditsky R, Black A, et al. Canadian consensus guidelines on continuous and extended hormonal contraception, 2007. J Obstet Gynaecol Can. 2007;195:S1–S32
  4. Anderson FD, Gibbons W, Portman D. Long-term safety of an extended-cycle oral contraceptive (Seasonale): a 2-year multicenter open-label extension trial. Am J Obstet Gynecol. 2006;195:92–96
  5. Archer DF, Jensen JT, Johnson JV, Borisute H, Grubb GS, Constantine GD. Evaluation of a continuous regimen of levonorgestrel/ethinyl estradiol: Phase 3 study results. Contraception. 2006;74:439–445
  6. Teichmann AT, Kluft C, Grubb G, Constantine G, Spielmann D. Comparative trial of continuous-use and 21-day cyclic levonorgestrel and ethinyl estradiol oral contraceptive. Obstet Gynecol. 2006;107(Suppl):12S
  7. Belsey EM. Menstrual bleeding patterns in untreated women and with long-acting methods of contraception. Task Force on Long-Acting Systemic Agents for Fertility Regulation. Adv Contracept. 1991;7:257–270

☆ clinicaltrials.gov Identifier: NCT00245921.

☆☆ This study was sponsored by Wyeth Research, which was acquired by Pfizer, Inc., in October 2009.

PII: S0010-7824(10)00355-0

doi: 10.1016/j.contraception.2010.06.002

Contraception
Volume 82, Issue 6 , Pages 497-502 , December 2010

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