Contraception
Volume 85, Issue 2 , Pages 150-154 , February 2012

Infection and extramural delivery with use of digoxin as a feticidal agent

  • Rachel Steward

      Affiliations

    • Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 646 417 1685 (Cell), +1 213 919 9864 (Pager); fax: +1 323 226 5046.
    • ,
  • Alexander Melamed

      Affiliations

    • Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    • ,
  • Renita Kim

      Affiliations

    • Planned Parenthood of Los Angeles, Los Angeles, CA 90033, USA
    • ,
  • Deborah Nucatola

      Affiliations

    • Planned Parenthood of Los Angeles, Los Angeles, CA 90033, USA
    • ,
  • Mary Gatter

      Affiliations

    • Planned Parenthood of Los Angeles, Los Angeles, CA 90033, USA

Received 28 October 2010 ,Revised 4 January 2011 ,Accepted 8 January 2011.

References 

  1. Grimes DA, Schulz KF. Morbidity and mortality from second-trimester abortions. J Reprod Med. 1985;30:505–514[Evidence Grade: III]
  2. Koonin LM, Strauss LT, Chrisman CE, Montalbano MA, Bartlett LA, Smith JC. Abortion surveillance — United States, 1996. MMWR Morb Mortal Wkly Rep. 1998;48:1–42
  3. Partial-Birth Abortion Ban Act, U.S.C. 1531. 2003.
  4. Diedrich J, Drey E. Induction of fetal demise before abortion. SFP guideline 20101. Release January 2010. Contraception. 2010;81:462–473
  5. Paul M, Lichtenberg ES, Borgatta L, Grimes DA, Stubblefield PG, Creinin MD. Management of unintended and abnormal pregnancy. In: Comprehensive abortion care. Oxford, UK: Wiley-Blackwell; 2009;p. 166;Chapter 11
  6. Nucatola D, Roth N, Gatter M. A randomized pilot study on the effectiveness and side effect profiles of two doses of digoxin as a feticide when administered intraamniotically or intrafetally prior to second-trimester surgical abortion. Contraception. 2010;81:67–74
  7. Jackson RA, Teplin VL, Drey EA, et al. Digoxin to facilitate late second-trimester abortion: a randomized, masked, placebo-controlled trial. Obstet Gynecol. 2001;97:471–476
  8. Drey EA, Thomas LJ, Benowitz NL, Goldschlager N, Darney PD. Safety of intraamniotic digoxin administration before late second-trimester abortion by dilation and evacuation. Am J Obstet Gynecol. 2000;185:1063–1066
  9. Molaei M, Jones HG, Weiselberg T, McManama M, Bassell J, Westhoff C. Effectiveness and safety of digoxin to induce fetal death prior to second-trimester abortion. Contraception. 2008;77:223–225[Evidence Grade II-3]
  10. Li Kim Mui SV, Chitrit Y, Boulanger MC, et al. Sepsis due to Clostridium perfringens after pregnancy termination with feticide by cordocentesis: a case report. Fetal Diagn Ther. 2002;17:124–126[Evidence Grade: III]
  11. Lipitz S, Shalev E, Meizner I, et al. Late selective termination of fetal abnormalities in twin pregnancies: a multicentre report. Br J Obstet Gynaecol. 1996;103:1212–1216[Evidence Grade: III]
  12. Timor-Tritsch IE, Peisner DB, Monteagudo A, et al. Multifetal pregnancy reduction by transvaginal puncture: evaluation of the technique used in 134 cases. Am J Obstet Gynecol. 1993;168:799–804[Evidence Grade: III]
  13. Dean G, Lunde B, Colarossi L, Jacobs A, Porsch L, Paul M. The safety and efficacy of digoxin as a feticidal agent prior to second trimester abortion by dilation and evacuation. Contraception. 2009;80:197;(abstract)
  14. Paul M, Lichtenberg ES, Borgatta L, Grimes DA, Stubblefield PG, Creinin MD. In: Management of unintended and abnormal pregnancy. Comprehensive abortion care. Oxford, UK: Wiley-Blackwell; 2009;p. 237;Chapter 15

☆ There was no funding for this study.

PII: S0010-7824(11)00006-0

doi: 10.1016/j.contraception.2011.01.005

Contraception
Volume 85, Issue 2 , Pages 150-154 , February 2012

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