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Abstract
Six 3-cm polydimethylsiloxane capsules containing 30 mg each of R-2323 were implanted
subdermally in each of 38 women to assess their effect upon fertility, menstrual pattern,
some aspects of metabolism and the incidence of side effects associated with the use
of this hormonal contraceptive. There were no pregnancies in a total of 292 months
of exposure. The longest duration of use was 12 months and the median was between
8 and 9 months. Amenorrhea and signs of androgenicity such as acne and hyperthricosis
were common complaints and a frequent reason for closure. Headache and nervousness
also were reported by a high proportion of patients. Blood and urine analyses were
normal with the exception of elevated transaminases in 20 out of 27 patients after
the third month of treatment. Side effects and elevation of the serum transaminase
levels disappeared promptly after removal of the implants in all cases. It is concluded
that R-2323 implants at the dose tested are potent inhibitors of fertility in women.
The high incidence of treatment-associated adverse reactions impose limitations on
their use in Chilean women.
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Article info
Publication history
Accepted:
May 16,
1977
Identification
Copyright
© 1977 Published by Elsevier Inc.
