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Abstract
This paper presents results of a double blind, multi-centered and multi-national study
of two progestin only subdermal implants used for contraception. A regimen of six
capsules of levonorgestrel (Ng) used by 492 women had a net cumulative 12-month pregnancy
rate of 0.6 percent and a continuation rate of 74.6 percent. 498 women used six capsules
of norgestrienone (R2010) and experienced a net cumulative 12-month pregnancy rate
of 3.5 percent and a continuation rate of 79.4 percent. The difference in the pregnancy
rate was significant at P <0.01, while there was no significant difference in the continuation rates. Menstrual
problems were the principal reason for termination of the levonorgestrel regimen,
accounting for approximately half of all terminations. There were significantly fewer
menstrual problems among users of the norgestrienone (R2010) capsules; the net cumulative
12-month termination rate for this reason was 4.3 percent. Results are compared with
continuation and termination rates for acceptors of the Copper T 200 at the same clinics.
The low pregnancy rate and reasonably high continuation rate of the norgestrel implants
coupled with the fact that the expected effective lifetime of a set of capsules is
of the order of 3–5 years appears to warrant further development of this contraceptive
regimen.
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References
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Article info
Publication history
Accepted:
September 1,
1978
Identification
Copyright
© 1978 Published by Elsevier Inc.
