Hemoglobin levels, blood pressure, body weight and the subjects' impressions of changes
in various conditions have been recorded during a multicentered study of levonorgestrel
and norgestrienone subdermal implants. Data from a group of women using the Copper
T 200 IUD at the same clinics and admitted under the same criteria are presented for
A major reason for termination of use of the levonorgestrel implants was disturbance
of menstrual patterns. When all subjects reported their experience with the two steroid
regimens, substantially larger proportions of subjects using levonorgestrel implants
noted changes in menstrual flow, duration of menses and intermenstrual bleeding and
spotting than was the case of women contracepting with norgestrienone implants. Relative
to the experience with implants, more users of the Copper T 200 in a control study
reported increased dysmenorrhea, and an increase in the amount and duration of menstrual
Despite the reported increases in menstrual flow and duration of bleeding, women using
subdermal implants of either contraceptive steroid, levonorgestrel and norgestrienone,
showed an increase in blood hemoglobin values during the course of one year of use.
In the control group using the TCu 200 IUD, no change in mean hemoglobin levels was
found. Neither mean systolic nor diastolic blood pressure of the women using steroids
was affected. There was a small net increase in weight among the users of steroids,
but none in the Copper T controls.
An increase in acne and other skin conditions was perceived by the same percentages
of women using Copper IUDs as women using the steroids. A greater proportion of IUD
acceptors noted increased nervousness and depression than was felt by the women contracepting
with the steroid implants.