Advertisement

A three-year clinical trial with levonorgestrel silastic implants

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Silastic implants containing the progestin, levonorgestrel, were tested as long-term contraceptives in 101 women. After three full years of exposure and 2,998 woman-months of use, no pregnancies had occurred. The continuation rates were 87% at 12 months, 79% at 24 months and 66% at 36 months. The most important side effect was excessive or irregular bleeding during the first year. No treatment was offered for this side effect other than vitamins and iron or change of method, with the exception of 3 cases where ethinyl estradiol was used one time for 2 weeks each. Bleeding disturbances led 8 patients to ask for removal of implants. Other side effects were headache, acne and lower abdominal pain. Blood and urine analysis tested 17 different parameters and all but plasma cortisol remained within normal limits throughout the study. A general tendency toward lowered Cortisol values was observed and two subjects had more than one value below the normal limit for the population during the study. Glucose tolerance tests during the second year were abnormal in two women with familial diabetes but they returned to normal values spontaneously at the next test.
      It is concluded that levonorgestrel implants offer effective protection against pregnancy during the first three years of continuous use. Their acceptability and few side effects justify larger trials, especially if treatment of bleeding irregularities is introduced.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Contraception
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Croxatto H.B.
        • Diaz S.
        Steroidal implants for contraception.
        in: Ebling FJG Henderson I.W. Biological and Clinical Aspects of Reproduction. Excerpta Medica, Amsterdam, Oxford1976: 386-389
        • Croxatto H.B.
        • Diaz S.
        • Quinteros E.
        • Simonetti L.
        • Kaplan E.
        • Rencoret R.
        • Leixelard P.
        • Martinez C.
        Clinical assessment of subdermal implants of megestrol acetate, d-norgestrel and norethindrone as a long-term contraceptive in women.
        Contraception. 1975; 12: 615
        • Coutinho E.M.
        • Da Silva A.R.
        One year contraception with norgestrienone subdermal silastic implants.
        Fertility and Sterility. 1974; 25: 170
        • Coutinho E.M.
        • Da Silva A.R.
        • Carreira C.M.
        • Chavez M.C.
        • Felhi J.A.
        Contraceptive effectiveness of silastic implants containing the progestin R2323.
        Contraception. 1975; 11: 625
        • Diaz S.
        • Pavez M.
        • Quinteros R.
        • Robertson D.N.
        • Croxatto H.B.
        Clinical trial with subdermal implants of the progestin R2323.
        Contraception. 1977; 16: 155
        • Diaz S.
        • Pavez M.
        • Quinteros E.
        • Diaz J.
        • Robertson D.
        • Croxatto H.B.
        Clinical trial with subdermal implants containing norgestrienone.
        Contraception. 1978; 18: 429
        • Rodriguez G.
        • Faundes A.L.
        • Atkinson L.E.
        Enfoque al analisis de patrones menstruales en la evaluacion critica de anticonceptivos.
        Estudios de Poblacion. 1976; 1: 90
        • Marinovic I.
        • Guerra C.
        • Larach G.
        Incidencia de litasis biliar en material de autopsias y analisis de la composicion de los calculos.
        Rev. Med. Chile. 1972; 100: 1320
      1. Contraception. 1978; 18: 335
      2. Contraception. 1978; 18: 315
        • Nash H.A.
        • Robertson D.N.
        • Moo Young A.J.
        • Atkinson L.E.
        Steroid release from silastic capsules and rods.
        Contraception. 1978; 18: 367