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Abstract
Comparative clinical trials of 2 sizes of contraceptive vaginal rings and of an oral
contraceptive were undertaken at 8 investigational sites (9 clinics). More than 500
women enrolled on each of the 3 study regimens. Side effects of the rings and of Nordette,
∗Nordette is a registered trademark of Wyeth-Pharma, Munster, West Germany.
the oral contraceptive, were evaluated by noting spontaneous complaints, by recording
medications taken and by physical examination. Inquiries about changes in the frequency
of specific conditions were made at the end of the subjects' participation in the
first year of the study. The incidence of spontaneous complaints was similar among
users of the 2 different-sized rings and of the pill. Vaginal and menstrual complaints
were significantly more frequent among ring users. Headaches, dizziness and nausea
were reported significantly more frequently by users of Nordette. All the regimens
were associated with weight gain and increased hemoglobin levels. Nordette was associated
with small but significant increases in both diastolic and systolic blood pressure.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
September 15,
1981
Received:
August 11,
1981
Identification
Copyright
© 1981 Published by Elsevier Inc.
