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Abstract
Menstrual events among users of contraceptive vaginal rings (CVRs), releasing levonorgestrel
and estradiol, were studied in comparison with a combined oral contraceptive, Nordette,
∗Nordette is a registered trademark of Wyeth-Pharma, Munster, West Germany.
in multicentered trials. CVRs were made with outside diameters of 50 and 58 mm and
released about 250 μg and 290 μg of levonorgestrel and 150 μg and 180 μg of estradiol
per day, respectively. The CVRs were used continuously for 3 weeks and then removed
for 1 week. Both the CVRs and Nordette were perceived to reduce menstrual flow and
days of menstrual bleeding. Twenty to 25% of CVR users perceived increased inter menstrual
bleeding or spotting. Diaries indicate, however, that on average, CVR users experienced
about 1 day per month of bleeding or spotting with the ring in place. CVRs and Nordette
produced approximately the same total number of bleeding and spotting days during
6 cycles of use, 27–29, but the small (50-mm OD) ring was associated with somewhat
more spotting. This ring was also associated with somewhat more prolonged bleeding
and spotting runs and with more prolonged nonbleeding intervals than reported by users
of the larger (58-mm OD) ring or of Nordette. Differences among regimens, however,
tended to be small even when statistically significant. Evidence from menstrual diaries
indicates that these CVRs, and in particular the 58-mm ring, provide control over
the menstrual cycle comparable to that of Nordette.To read this article in full you will need to make a payment
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References
- A Cross-Cultured Study of Menstruation: Implication for Contraceptive Development and Use.Stud. Fam. Plann. 1981; 12: 3-16
- Clinical performance and endocrine profiles with contraceptive vaginal rings containing a combination of estradiol and d-norgestrel.Amer. J. Obstet. Gynecol. 1978; 130: 55
- Clinical performance and endocrine profile with contraceptive vaginal rings containing a combination of estradiol and d-norgestrel.Contraception. 1981; 23: 241-250
- A multicenter study of levonorgestrel-estradiol contraceptive vaginal rings. I — Use effectiveness. An international comparative trial.Contraception. 1981; 24: 341-358
- A multicenter study of levonorgestrel-estradiol contraceptive vaginal rings. II — Subjective and objective measures of effects. An international comparative trial.Contraception. 1981; 24: 359-376
- An approach to the analysis of menstrual patterns in the critical evaluation of contraceptives.Stud. Fam. Plann. 1976; 7: 42-51
Article info
Publication history
Accepted:
September 15,
1981
Received:
August 11,
1981
Identification
Copyright
© 1981 Published by Elsevier Inc.
