Advertisement
Contraception
Advanced searchSave search
Research Article| Volume 25, ISSUE 5, P447-456, May 1982

Download started.

Ok

A five-year clinical trial of levonorgestrel silastic implants (Norplant™)

DOI:https://doi.org/10.1016/0010-7824(82)90033-6
A five-year clinical trial of levonorgestrel silastic implants (Norplant™)
Next ArticlePlasma protein binding of norethisterone
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Silastic implants containing the progestin, levonorgestrel, were tested as a long-term contraceptive system in 101 women. During five full years of use, no pregnancies occurred. The 5-year continuation rate was 54%. Menstrual irregularities were the most frequent reason for termination of use but only during the first year. More than half of the terminations for this reason were in the first year. Some of the subjects elected to continue use of the implants beyond 5 years, allowing release rate data to be obtained through 6 years.
      From the second through the sixth year of use, the implants delivered a constant 30 micrograms per day of levonorgestrel to the subjects, and even after six years 57% of the original steroid content remained in the capsules.
      Return of fertility following removal was essentially immediate and not related to time of use. Medical reasons for removal were infrequent and no pattern was discernible.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Contraception
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • The International Committee for Contraception Research of the Population Council^
        Contraception with long-acting subdermal implants.
        Contraception. 1978; 18: 315-333
        • Sivin I.
        • Robertson D.N.
        • Stern J.
        • Croxatto H.B.
        • Diaz S.
        • Coutinho E.
        • da Silva A.R.
        • Alvarez F.
        • Faundes A.
        • McDonald O.
        • Holma P.
        • Nielsen N.C.
        • Osler M.
        • Nash H.A.
        NORPLANT, reversible implant contraception.
        Studies in Family Planning. 1980; 11: 227-235
        • Diaz S.
        • Pavez M.
        • Robertson D.N.
        • Croxatto H.B.
        A three-year clinical trial with levonorgestrel Silastic implants.
        Contraception. 1979; 19: 557-573
        • Nash H.A.
        • Robertson D.N.
        • Moo-Young A.J.
        • Atkinson L.E.
        Steroid release from Silastic capsules and rods.
        Contraception. 1978; 18: 367-394
        • Croxatto H.B.
        • Diaz S.
        • Miranda P.
        • Elamsson K.
        • Johansson E.D.B.
        Plasma levels of levonorgestrel in women during long-term use of NORPLANT.
        Contraception. 1981; 23: 197-209

      Article info

      Publication history

      Accepted: April 12, 1982
      Received: February 10, 1982

      Identification

      DOI: https://doi.org/10.1016/0010-7824(82)90033-6

      Copyright

      © 1982 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX