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Abstract
Polydimethylsiloxane (Silastic) capsules containing megestrol acetate have been implanted
in subcutaneous tissue as a method of long-term contraception. Histological studies
revealed a granulomatous foreign body reaction around these capsules with birefringent
crystals in multinucleated giant cells. Although several authors had interpreted these
crytals as steroids, this seemed unlikely since the tissue had been processed with
organic solvents. Analysis of these crystals by polarization microscopy, scanning
electron microscopy, and X-ray microanalysis demonstrated that the material was talc.
The talc was probably introduced as a contaminant from gloves during the implantation.
Further analysis showed that capsule fragmentation could not have produced the material
since Silastic particles could not be detected.
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References
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Article info
Publication history
Accepted:
February 3,
1984
Received:
January 25,
1984
Identification
Copyright
© 1984 Published by Elsevier Inc.
