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Clinical chemistry in women treated with six levonorgestrel covered rods or with a copper IUD

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      Abstract

      A group of women treated with six levonorgestrel covered rods participated in a study on general chemistry and blood levels of selected hormones at treatment months 20 and 65. A comparable group of Copper T users served as control. Parameters analyzed were the SMA 12 chemistry profile, estradiol, testosterone, cortisol, T3, T4 and TSH. Samples from treated and control subjects were drawn within the same calendar period and were run simultaneously for the assay of each parameter.
      The values observed were within the normal limits. Significantly higher values of total protein and albumin and lower levels of estradiol and testosterone were found among implant users when compared to the control group. The results suggests little or no metabolic changes in users of six levonorgestrel covered rods which release a daily dose of approximately 105 micrograms.
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      References

        • Faundes A.
        • Brache V.
        • Leon P.
        • Robertson D.
        • Alvarez F.
        First year clinical experience with six levonorgestrel rods as subdermal contraception.
        Contraception. 1979; 20: 167-175
      1. Robertson, D.N., Diaz, S., Alvarez-Sanchez, F., Holma, P., Mishell, D.R., Coutinho, E., Brache, V., Croxatto, H.B., Faundes, F., Lacarra, M., Pavez, M., Roy, S., da Silva, A.R., Sivin, I., and Stern, J. Contraception with Long-Acting Subdermal Implants. A Five-Year Clinical Trial with Silastic Covered Rod Implants Containing Levonorgestrel. In press.

        • Robertson D.N.
        • Sivin I.
        • Nash H.A.
        • Braun J.
        • Dinh J.
        Release rates of levonorgestrel from Silastic capsules, homogenous rods and covered rods in humans.
        Contraception. 1983; 27: 483-495
        • Croxatto H.B.
        • Diaz S.
        • Robertson D.N.
        • Pavez M.
        Clinical chemistry in women treated with levonorgestrel implants (Norplant)or a TCu 200 IUD.
        Contraception. 1983; 27: 281-288
        • International Committee for Contraception Research
        Contraception with long-acting subdermal implants. I. An effective and acceptable modality in international clinical trial.
        Contraception. 1978; 18: 315-333
        • International Committee for Contraception Research
        Contraception with long-acting subdermal implants: II. Measured and perceived effects in international clinical trial.
        Contraception. 1978; 18: 335-353
        • Kammen E.V.
        • Thijssen J.H.H.
        • Rademaker B.
        • Schwarz F.
        The influence of hormonal contraceptives on sex hormone binding globulin (SHBG) capacity.
        Contraception. 1975; 11: 53-59
        • Victor A.
        • Weiner E.
        • Johansson E.D.B.
        Sex hormone binding globulin: the carrier protein for d-norgestrel.
        J Clin Endocrinol Metab. 1976; 43: 244-247
        • Osman M.I.
        • Abdalla M.I.
        • Toppozada M.H.
        • Bayad M.A.
        • Ibrahim I.I.
        • Hafez E.S.E.
        Subdermal levonorgestrel implants: Serum androgens.
        Contracept Deliv Syst. 1983; 4: 127-131
      2. Olsson, S-E., Odlind, V., Johansson, E.D.B. Androgen levels in women using NorplantR implants. Contraception, submitted.