Advertisement

Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      A total of 189 women volunteered to accept subdermal implants for contraception. The implants were “covered rods”, consisting of a core rod containing equal parts by weight of levonorgestrel and polydimethylsiloxane and sealed inside a thin-walled tube of Silastic tubing with medical adhesive. In one study 78 women used 4 3cm rods (study 07) and in the other 111 women used 6 3cm rods. In 5 years of use there were no pregnancies in either group. Terminations because of menstrual problems were twice as frequent among the 4-rod users than among users of the 6 rods. Menstrual pattern analysis is presented for the two rod regimens and compared with the previously reported patterns for the 6-capsule regimen (NORPLANTR). Long-term Math Eq release rates are also presented.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Contraception
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. ICCR Contraception. 1978; 18 (I): 315-333
      2. Special Issue Studies in Family Planning. 1983; 14: 159-193
        • Diaz S.
        • Pavez M.
        • Miranda P.
        • Robertson D.N.
        • Sivin I.
        • Croxatto H.B.
        A Five-Year Clinical Trial of Levonorgestrel Silastic Implants (NORPLANT).
        Contraception. 1982; 25: 447-456
        • Nash H.A.
        • Robertson D.N.
        • Moo-Young A.J.
        • Atkinson L.E.
        Steroid Release from Silastic Capsules and Rods.
        Contraception. 1978; 18: 367-394
        • Faundes A.
        • Mejias V.B.
        • DeLeon P.
        • Robertson D.
        • Alvarez F.
        First year clinical experience with six levonorgestrel rods as subdermal contraception.
        Contraception. 1979; 20: 167-175
        • Roy S.
        • Stanczyk F.
        • Mishell D.R.
        • Lumkin M.
        • Gentzschein E.
        Clinical and Endocrinological Study of Continuous Levonorgestrel Administration from Subcutaneous Solid Polydimethylsiloxane Rods.
        Contraception. 1980; 21: 595-615
        • Weiner E.
        • Johansson E.D.B.
        Contraception with d-Norgestrel Silastic Rods: Plasma Levels of d-Norgestrel and Influence on the Ovarian Function.
        Contraception. 1976; 14: 551-562
        • Robertson D.N.
        • Sivin I.
        • Nash H.A.
        • Braun J.R.
        • Dinh J.
        Release Rates of Levonorgestrel from SilasticR Capsules. Homogenous Rods and covered Rods in Humans.
        Contraception. 1983; 27: 483-495
        • Jain A.
        • Sivin I.
        Life-Table Analysis of IUDs. Problems and Recommendations.
        Studies in Family Planning. 1977; 8
        • Faundes A.
        • Sivin I.
        • Stern J.
        Long -Acting Contraceptive Implants, An Analysis of Menstrual Bleeding Patterns.
        Contraception. 1978; 18: 355-365