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Abstract
IUDs releasing 20 mcg/day of levonorgestrel (LNg20) were in randomized trial together
with the Copper T, model TCu 380Ag, in seven centers involving 2244 women. Two-year
(25 months) gross cumulative pregnancy rates were 0.2 ± 0.2 and 0.9 ± 0.3 for the
levonorgestrel and copper releasing devices, respectively (P > 0.05). There were no
ectopic pregnancies in more than 1600 woman-years of use of each device. Removal rates
for bleeding and/or pain or for medical reasons other than menstrual problems did
not differ significantly between devices. Oligomenorrhea or amenorrhea prompted 10.7
per hundred (gross rate, 8.4 net rate) women using the LNg 20 IUD to request removal
in the two-year period, significantly above the 0.2 per hundred rate among women with
the Copper IUD (P < 0.001). At the end of two years an estimated 59.4 per 100 women
were continuing use of the LNg 20 IUD, and 67.5 per 100 (P < 0.001) with the TCu 380Ag.
This difference is almost wholly ascribable to a marked reduction in bleeding episodes
and days among women using the LNg 20 device with concomitant removal of device. Hemoglobin
rose an average of 0.5g/dl (P < 0.001) for this group whereas women using the TCu
380Ag experienced a decline of 0.2g/dl compared with baseline values (P < 0.001).
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Article info
Publication history
Accepted:
April 7,
1987
Received:
February 10,
1987
Identification
Copyright
© 1987 Published by Elsevier Inc.
