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Abstract
Norethindrone, ethinylestradiol and diethylstilbestrol were administered during the
luteal phase in 31 menstrual cycles in rhesus monkeys. In eight of these cycles, chorionic
gonadotrophin was administered when treatment with the compounds was discontinued.
The effects of the compounds on the estrogen levels in plasma were insignificant.
During treatment with norethindrone, progesterone levels decreased. A slight increase
after treatment occurred in some cycles. Treatment with diethylstilbestrol resulted
in an initial depression followed by an increase of plasma progesterone levels. The
progesterone levels either increased or remained unchanged during and after ethinylestradiol
treatment. Chorionic gonadotrophin administration after treatment with the compounds
resulted in rapid surges of both progesterone and estrogen levels in the monkeys treated
with the estrogens, but not in the monkeys treated with norethindrone.
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Article info
Publication history
Accepted:
January 29,
1974
Identification
Copyright
© 1974 Published by Elsevier Inc.