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Norethindrone, ethinylestradiol and diethylstilbestrol were administered during the luteal phase in 31 menstrual cycles in rhesus monkeys. In eight of these cycles, chorionic gonadotrophin was administered when treatment with the compounds was discontinued. The effects of the compounds on the estrogen levels in plasma were insignificant.
During treatment with norethindrone, progesterone levels decreased. A slight increase after treatment occurred in some cycles. Treatment with diethylstilbestrol resulted in an initial depression followed by an increase of plasma progesterone levels. The progesterone levels either increased or remained unchanged during and after ethinylestradiol treatment. Chorionic gonadotrophin administration after treatment with the compounds resulted in rapid surges of both progesterone and estrogen levels in the monkeys treated with the estrogens, but not in the monkeys treated with norethindrone.
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Accepted: January 29, 1974
© 1974 Published by Elsevier Inc.