Research Article| Volume 9, ISSUE 4, P379-392, April 1974

A study of the effect of an oral contraceptive on blood coagulation factors, platelets and fibrinolytic activity

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      Blood coagulation factors I, II, VII, VIII and X were assayed before and after the intake of combination steroid contraceptive tablets containing 1 mg norethindrone acetate and 0.05 mg ethinyl estradiol, for six months, and also after their long-term use for two or more years. In both groups, there was a significant increase in factors I, II, VII and X, while factor VIII (antihaemophilia globulin) showed no significant change. Platelet count and bleeding time showed no change, but platelet adhesiveness was increased. There was also shortening of the euglobulin lysis time, which means an increased activity of fibrinolytic stimulants.
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        • Donayre J.
        • Pincus G.
        Effect of Enovid on blood clotting factors.
        Metabolism. 1965; 14: 418
        • Owren P.A.
        Coronary thrombosis. Its mechanism and possible prevention by linolenic acid.
        Ann. Int. Med. 1965; 63: 167
        • Poller L.
        • Thomson J.M.
        • Tabiowo A.
        • Priest C.M.
        Progesterone oral contraception and blood coagulation.
        Brit. Med. J. 1969; 1: 554
        • Lempert H.
        Practical Clinical Biochemistry, Plasma proteins, by Harold Varley.
        in: 3rd Edition. William Heinemann Medical Books, London1962: 191
        • Biggs R.
        • Macfarlane R.G.
        Human Blood Coagulation and its Disorders.
        in: 3rd Edition. Blackwell Scientific Publications, Oxford1963: 81
        • Denson K.W.E.
        The specific assay of Prower-Stuart factor and factor VII.
        Acta Haemat. 1961; 25: 105
        • Biggs R.G.
        • Eveling J.
        • Richards G.
        The assay of antihaemophilic globulin activity.
        Brit. J. Haemat. 1955; 1: 20
        • Denson K.W.E.
        The simplified two-stage assay for factor VIII, using a combined reagent.
        Transact. Internat. Committ. Haemostasis & Thrombosis, Chapel Hill, N.C. U.S.A1967 (Dec. 1966)
        • Brecher G.
        • Cronkite E.R.
        Morphology and enumeration of human blood platelets.
        J. Appl. Physiol. 1950; 3: 365
        • Hellem J.A.
        The adhesiveness of human blood platelets Math Eq.
        Scand. J. Clin. Lab. Invest. 1960; 51: 12
        • Duke W.W.
        Bleeding time.
        JAMA. 1910; 55: 1185
        • Milstone H.
        A factor in normal human blood which participates in streptococcal fibrinolysis.
        J. Immuno. 1941; 42: 109
        • Souka A.R.
        Liver function study under the effect of oral contraceptives.
        in: M.Ch. Thesis. University of Alexandria, EGYPT1969
        • Ygge J.
        • Brody S.
        • Korsan-Bengssen K.
        • Nilsson L.
        Changes in blood coagulation and fibrinolysis in women receiving oral contraceptives.
        Am. J. Obstet. Gynec. 1969; 104: 87
        • Haller J.
        • Koenig A.
        • Poliwoda H.
        Geburtsh. U. Frauen. 1965; 25: 215
        • Beller F.K.
        • Porges R.F.
        Blood coagulation and fibrinolytic enzyme system during cyclic and continuous application of progestational agents.
        Am. J. Obstet. Gynec. 1967; 97 (quoted by): 448
        • Sobrero A.J.
        • Fenichel R.L.
        • Singher H.O.
        Effects of progestin-oestrogen preparation on blood coagulation mechanisms.
        JAMA. 1963; 185: 136
        • Margulis R.R.
        • Ambrus J.L.
        • Mink I.P.
        • Stryker J.C.
        Progestational agents and blood coagulation.
        Am. J. Obstet. Gynec. 1965; 93: 161
        • Crowell Jr., E.B.
        • Clatnoff D.V.
        • Kiekhofer W.
        The effect of oral contraceptives on Factor VIII levels.
        J. Lab. Clin. Med. 1971; 77: 551
        • Howie P.W.
        • Mallinson A.C.
        • Prentice C.R.M.
        • Horne C.H.W.
        • McNicol G.P.
        Effect of combined oestrogen-progestogen oral contraceptives, oestrogen and progestogen on antiplasmin and antithrombin activity.
        Lancet. 1970; 2: 1329
        • Nilsson I.M.
        • Kullander S.
        Coagulation and fibrinolytic studies during the use of gestagens.
        Acta Obstet. and Gynec. Scand. 1967; 46: 286
        • Poller L.
        • Thomson J.M.
        Clotting factors during oral contraception. Further report.
        Brit. Med. J. 1966; 2: 23
        • Poller L.
        Thrombosis and factor VII activity.
        J. Clin. Path. 1957; 10: 348
        • Schiffman S.
        • Rapaport S.I.
        Increased factor VIII level in suspected carriers of “haemophilia A” taking contraceptives by mouth.
        New Engl. J. Med. 1966; 275: 599
        • Quick A.J.
        Oral contraception and coagulability.
        Brit. Med. J. 1963; 1: 744
        • Godal H.C.
        • Madsen K.
        • Meyer N.R.
        Thromboembolism in patients with total proconvertin (Factor VII) deficiency. A report of two cases.
        Acta Med. Scand. 1962; 171: 325
        • Schorgie J.J.
        • Solomon H.M.
        • Zieve P.D.
        Effect of oral contraception on vitamin K-dependent clotting activity.
        Clin. Pharm. Therap. 1967; 8: 670
        • Pepper H.
        • Lindsay S.
        Levels of platelets and eosinophilic leucocytes during the normal menstrual cycle and the administration of norethynodrel (Enovid).
        Inter. J. Fert. 1963; 8: 467
        • Miller S.P.
        • Lee S.L.
        • Ritz N.
        Progestin-oestrogen (Sch 11,800) therapy and haemostatic meachanisms — a control study.
        Metabolism. 1965; 14: 398
        • Ham J.M.
        • Rose R.
        Platelet adhesiveness and lipoprotein lipase activity in controls and in subjects taking oral contraceptives.
        Am. J. Obstet. Gynec. 1969; 105: 628
        • Caspary E.A.
        • Peberdy M.
        Oral contraception and blood platelet adhesiveness.
        Lancet. 1965; 1: 1142
        • Starlinger W.
        • Sametnik S.
        Ueber die Entsehungsbedingungen der spontanen venenthrombose.
        Klin. Wschncher. 1927; 6: 1269
        • Moolten S.E.
        • Wroman L.
        • Wroman G.M.S.
        • Goodman B.
        Role of blood platelets in thromboembolism.
        Arch. Int. Med. 1949; 84 (quoted by): 667
        • Bennett N.B.
        • Bennett P.N.
        • Fullerton H.W.
        • Ogston C.M.
        • Ogston D.
        Effect of oestriol on platelet adhesiveness and fibrinolysis in man.
        Lancet. 1966; 2: 881
        • Toppozada H.K.
        • Youssef H.A.
        Evaluation of oral contraception.
        Bull., Alex. Fac. Med. 1965; 1: 403
        • Brakman P.
        • Sobrero A.J.
        • Astrup T.
        Effects of different systemic contraceptives on blood fibrinolysis.
        Am. J. Obstet. Gynec. 1970; 106: 187
        • Rutherford R.N.
        • Hougie C.
        • Banks A.L.
        • Coburn W.A.
        The effects of sex steroids and pregnancy on blood coagulation factors. A comparative study.
        Obstet. & Gynec. 1964; 24: 886
        • Bick R.L.
        • Thompson W.B.
        Fibrinolytic activity: Changes with oral contraceptives.
        Obstet. & Gynec. 1972; 39: 213