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Abstract
The ability of antibodies generated by the vaccine Pr-β-HCG-TT in two species of animals
to neutralize the biological activity of HCG has been investigated. The antisera from
an immunized goat and serveral rhesus monkeys (
) abolished the HCG induced rise in ventral prostate weight of immature male rats
and of uterine weight in prepubertal mice. These were also found to be effective in
preventing the binding of 125I-HCG to receptors in rat testes and goat corpora lutea preparations. The antisera
also blocked the HCG induced synthesis and secretion of progesterone in corpus luteum
slices
. These investigations show that the antibodies elicited by the conjugate (Pr-β-HCG-TT)
form a complex with HCG, which is biologically inactive.


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References
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Article info
Publication history
Accepted:
October 20,
1975
Identification
Copyright
© 1976 Published by Elsevier Inc.