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Abstract
The ability of Pr-β-HCG-TT vaccine to elicit anti-HCG antibodies have been investigated
in four human subjects who were in reproductive age and of proven fertility. All subjects
responsed positively by formation of anti-HCG and anti-tetanus toxoid antibodies.
The anti-HCG antibodies were detectable after a lag period of 6 to 8 weeks and plateau
levels were attained at about five months after primary immunization with the vaccine.
The anti-HCG antibody titers though declining were still high in three subjects after
nearly 11 months of immunization. In one of the subjects the titers declined to near
zero levels after 16 months indicating the reversibility of antibody response with
this vaccine. The antibodies reacted immunologically with the whole HCG molecule and
were competent to neutralize the biological activity of HCG in radioligand receptor
assay.
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References
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Article info
Publication history
Accepted:
October 20,
1975
Identification
Copyright
© 1976 Published by Elsevier Inc.
