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Abstract
Four women in child bearing age group were immunized with the vaccine Pr-β-HCG-TT.
All of them responded to active isoimmunization by production of anti-HCG and anti-TT
antibodies. All subjects were followed up for one year. A thorough clinical examination
was done at monthly visits and nothing abnormal was detected. Laboratory examination
included (i) Hepatic function (serum bilirubin, alkaline phosphatase, serum transaminases
GOT and GPT, LDH isoenzymes, cholinesterase), (ii) Renal function tests (urine routine
and microscopic examination, blood urea and serum creatinine and urinary creatinine,
(iii) Metabolic studies (blood glucose, serum proteins, serum cholesterol, and free
fatty acids), (iv) Endocrinal study (protein-bound-iodine, insulin tolerance test
serum progesterone and endometrial biopsy) and (v) Haematological investigations (haemoglobin,
total and differential leucocyte count, erythrocyte sedimentation rate, platelet reticulocyte
count and peripheral smear). No abnormality of any kind has been noticed so far, thus
indicating that active isoimmunization with Pr-β-HCG-TT has no adverse or undesirable
side effects.
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Article info
Publication history
Accepted:
October 20,
1975
Identification
Copyright
© 1976 Published by Elsevier Inc.
