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Four women in child bearing age group were immunized with the vaccine Pr-β-HCG-TT. All of them responded to active isoimmunization by production of anti-HCG and anti-TT antibodies. All subjects were followed up for one year. A thorough clinical examination was done at monthly visits and nothing abnormal was detected. Laboratory examination included (i) Hepatic function (serum bilirubin, alkaline phosphatase, serum transaminases GOT and GPT, LDH isoenzymes, cholinesterase), (ii) Renal function tests (urine routine and microscopic examination, blood urea and serum creatinine and urinary creatinine, (iii) Metabolic studies (blood glucose, serum proteins, serum cholesterol, and free fatty acids), (iv) Endocrinal study (protein-bound-iodine, insulin tolerance test serum progesterone and endometrial biopsy) and (v) Haematological investigations (haemoglobin, total and differential leucocyte count, erythrocyte sedimentation rate, platelet reticulocyte count and peripheral smear). No abnormality of any kind has been noticed so far, thus indicating that active isoimmunization with Pr-β-HCG-TT has no adverse or undesirable side effects.
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Accepted: October 20, 1975
© 1976 Published by Elsevier Inc.